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DC Field | Value | Language |
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dc.contributor.author | de Salazar, Lydia | - |
dc.contributor.author | Torregrosa-Garcia, Antonio | - |
dc.contributor.author | Luque-Rubia, Antonio J. | - |
dc.contributor.author | Avila-Gandia, Vicente | - |
dc.contributor.author | Domingo i Pedrol, Joan Carles | - |
dc.contributor.author | López Román, Fco. Javier | - |
dc.date.accessioned | 2020-11-30T17:52:43Z | - |
dc.date.available | 2020-11-30T17:52:43Z | - |
dc.date.issued | 2020-11-18 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172471 | - |
dc.description.abstract | Docosahexaenoic acid (DHA) supplementation can reduce exercise-induced oxidative stress generated during long aerobic exercise, with the minimum dose yet to be elucidated for physically active subjects. In this study, we performed a dose finding with re-esterified DHA in triglyceride form in a randomized double-blind parallel trial at different doses (350, 1050, 1750, and 2450 mg a day) for 4 weeks in males engaged in regular cycling (n = 100, 7.6 ± 3.7 h/week). The endogenous antioxidant capacity of DHA was quantified as a reduction in the levels of the oxidative stress marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) recollected in 24-h urine samples after 90 min of constant load cycling before and after intervention. To ascertain incorporation of DHA, erythrocyte polyunsaturated fatty acid (PUFA) composition was compared along groups. We found a dose-dependent antioxidant capacity of DHA from 1050 mg with a trend to neutralization for the highest dose of 2450 mg (placebo: n = 13, F = 0.041; 350 mg: n = 10, F = 0.268; 1050 mg: n = 11, F = 7.112; 1750 mg: n = 12, F = 9.681; 2450 mg: n = 10, F = 15.230). In the erythrocyte membrane, the re-esterified DHA increased DHA and omega-3 percentage and decreased omega 6 and the omega-6 to omega-3 ratio, while Eicosapentaenoic acid (EPA) and PUFA remained unchanged. Supplementation of re-esterified DHA exerts a dose-dependent endogenous antioxidant property against moderate-intensity long-duration aerobic exercise in physically active subjects when provided at least 1050 mg a day for 4 weeks. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/antiox9111145 | - |
dc.relation.ispartof | Antioxidants, 2020, vol. 9, num. 11, p. 1145 | - |
dc.relation.uri | https://doi.org/10.3390/antiox9111145 | - |
dc.rights | cc-by (c) de Salazar, Lydia et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Estrès oxidatiu | - |
dc.subject.other | Oxidative stress | - |
dc.title | Oxidative stress in endurance cycling is reduced dose-dependently after one month of re-esterified DHA supplementation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 704910 | - |
dc.date.updated | 2020-11-30T17:52:43Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33218112 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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704910.pdf | 1.35 MB | Adobe PDF | View/Open |
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