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http://hdl.handle.net/2445/172534
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DC Field | Value | Language |
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dc.contributor.author | Ferrà, Christelle | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.contributor.author | Gallardo, David | - |
dc.contributor.author | Berlanga, Juan J. | - |
dc.contributor.author | Rueda, Fèlix, 1951- | - |
dc.contributor.author | Marín, David | - |
dc.contributor.author | Banda, Esmeralda de la | - |
dc.contributor.author | Ancín, Idoia | - |
dc.contributor.author | Peris, Juan | - |
dc.contributor.author | García, Juan | - |
dc.contributor.author | Grañena Batista, Alberto | - |
dc.date.accessioned | 2020-12-03T15:06:51Z | - |
dc.date.available | 2020-12-03T15:06:51Z | - |
dc.date.issued | 1998-12-01 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172534 | - |
dc.description.abstract | Background and objective: the relationship between cytokine concentrations and transplant-related complications has been studied in bone marrow transplant patients. The changes in TNF-alpha, IL-1 and IL-6 concentrations after transplantation are well documented in the literature but this is not the case for IL-8. The purpose of the present study was to investigate prospectively the plasma concentration of these cytokines and their relationship to transplant-related complications. Design and methods: pro-inflammatory cytokine (TNF-alpha, IL-1, IL-6 and IL-8) levels in plasma were determined in a group of 53 patients undergoing hematopoietic progenitor transplantation. Plasma samples were collected weekly from day -7 to day +35 and stored at -70 degrees C until assayed by ELISA. The major transplant-related toxicities registered were: veno-occlusive disease (VOD), acute graft-versus-host disease (GVHD), infectious episodes, renal failure and mucositis. Results: in spite of the great variability of plasma cytokine profiles between the different patients, we came to various conclusions. Patients' TNF-alpha and IL-1 concentrations correlated well over time. IL-6 and IL-8 profiles were similar and correlated well with febrile episodes. In some cases, an increase in IL-6 preceded hematologic recovery. In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels. Allogeneic transplant patients had a tendency to have higher TNF-alpha concentrations than autologous transplant patients, probably because an allogeneic transplant is associated with more transplant-related toxicity. Basal disease usually had no effect on cytokine profiles. Interpretation and conclusions: IL-6 and IL-8 were the only cytokines studied whose increase correlated with febrile episodes. High IL-8 values may be a useful predictor of renal dysfunction and pulmonary disease and seems to trigger off high IL-6 levels. Plasma TNF-alpha and IL-1 concentrations during the posttransplant period have not been shown to be predictive of the development of transplant-related complications, and none of the profiles was recognized to be specific for a particular complication in this study. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://haematologica.org/issue/view/52 | - |
dc.relation.ispartof | Haematologica, 1998, vol. 83, num. 12, p. 1082-1087 | - |
dc.rights | (c) Ferrata Storti Foundation, 1998 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Medul·la òssia | - |
dc.subject.classification | Sang | - |
dc.subject.classification | Hematopoesi | - |
dc.subject.classification | Interleucines | - |
dc.subject.other | Bone marrow | - |
dc.subject.other | Blood | - |
dc.subject.other | Hematopoiesis | - |
dc.subject.other | Interleukins | - |
dc.title | IL-6 and IL-8 levels in plasma during hematopoietic progenotor transplant | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 546360 | - |
dc.date.updated | 2020-12-03T15:06:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 9949625 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Ciències Clíniques) |
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File | Description | Size | Format | |
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546360.pdf | 153.11 kB | Adobe PDF | View/Open |
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