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http://hdl.handle.net/2445/172553
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DC Field | Value | Language |
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dc.contributor.author | Huerga Encabo, Hector | - |
dc.contributor.author | Traveset, Laia | - |
dc.contributor.author | Argilaguet, Jordi | - |
dc.contributor.author | Angulo Aguado, Ana | - |
dc.contributor.author | Nistal Villán, Estanislao | - |
dc.contributor.author | Jaiswal, Rahul | - |
dc.contributor.author | Escalante, Carlos R. | - |
dc.contributor.author | Gekas, Christos | - |
dc.contributor.author | Meyerhans, Andreas | - |
dc.contributor.author | Aramburu, Jose | - |
dc.contributor.author | López Rodríguez, Cristina | - |
dc.date.accessioned | 2020-12-03T16:03:29Z | - |
dc.date.available | 2020-12-03T16:03:29Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172553 | - |
dc.description.abstract | Type I interferon (IFN-I) provides effective antiviral immunity but can exacerbate harmful inflammatory reactions and cause hematopoietic stem cell (HSC) exhaustion; therefore, IFN-I expression must be tightly controlled. While signaling mechanisms that limit IFN-I induction and function have been extensively studied, less is known about transcriptional repressors acting directly on IFN-I regulatory regions. We show that NFAT5, an activator of macrophage pro-inflammatory responses, represses Toll-like receptor 3 and virus-induced expression of IFN-I in macrophages and dendritic cells. Mice lacking NFAT5 exhibit increased IFN-I production and better control of viral burden upon LCMV infection but show exacerbated HSC activation under systemic poly(I:C)-induced inflammation. We identify IFNβ as a primary target repressed by NFAT5, which opposes the master IFN-I inducer IRF3 by binding to an evolutionarily conserved sequence in the IFNB1 enhanceosome that overlaps a key IRF site. These findings illustrate how IFN-I responses are balanced by simultaneously opposing transcription factors. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Rockefeller University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1084/jem.20190449 | - |
dc.relation.ispartof | Journal of Experimental Medicine, 2020, vol. 3, p. e20190449 | - |
dc.relation.uri | https://doi.org/10.1084/jem.20190449 | - |
dc.rights | cc by-nc-sa (c) Huerga Encabo et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es/ | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Interferó | - |
dc.subject.classification | Macròfags | - |
dc.subject.other | Interferon | - |
dc.subject.other | Macrophages | - |
dc.title | The transcription factor NFAT5 limits infection-induced type I interferon responses | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 699662 | - |
dc.date.updated | 2020-12-03T16:03:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31816635 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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699662.pdf | 4.56 MB | Adobe PDF | View/Open |
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