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Title: Sutton Naevi as melanoma simulators: Can confocal microscopy help in the diagnosis?
Author: Brugués, Albert
Ribero, Simone
Martins da Silva, Vanessa
Aguilera, Paula
García Herrera, Adriana
Alós i Hernández, Llúcia
Malvehy, J. (Josep)
Puig i Sardà, Susana
Carrera Álvarez, Cristina
Keywords: Melanoma
Microscòpia confocal
Confocal microscopy
Issue Date: 11-May-2020
Publisher: Society for the Publication of Acta Dermato-Venereologica
Abstract: Sutton naevi can sometimes present a challenging appearance with atypical presentation, also by dermoscopy. Reflectance confocal microscopy could help in making a diagnosis. This study prospectively collected two groups of Sutton nevi: the first one was composed by typical white halo naevi monitored for one year (13, 23%) and the second one was made up of atypical lesions excised in order to rule out melanoma, which were histologically diagnosed as Sutton naevi (21, 37%). These two groups of Sutton naevi were compared to a retrospectively collected cohort of thin melanomas with histologic regression features (23, 40%). On dermoscopy, atypical Sutton naevi and melanomas were indistinguishable. Reflectance confocal microscopy demonstrated significant differences at the dermo-epidermal junction: marked dermo-epidermal junction thickening and non-edged papilla were associated with melanoma, while the presence of nests was associated with Sutton naevi. However, reflectance confocal microscopy also detected marked intraepidermal pagetoid cells in Sutton naevi that were a combination of MelanA+ and CD1a+ cells. Sutton naevi can simulate melanoma, under both dermoscopy and reflectance confocal microscopy. Nevertheless, relevant confocal dermo-epidermal junction features and the clinical scenario can be helpful to make a final diagnosis, especially in those situations where melanoma must be ruled out.
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It is part of: Acta Dermato-Venereologica, 2020, vol. 100, num. 10, p. adv00134
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ISSN: 0001-5555
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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