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http://hdl.handle.net/2445/172610
Title: | Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved. |
Author: | Afelik, Solomon Rovira, Meritxell |
Keywords: | Pàncrees Cèl·lules B Gens Pancreas B cells Genes |
Issue Date: | 16-May-2017 |
Publisher: | BioMed Central |
Abstract: | Diabetes mellitus is a metabolic disorder characterized by dysfunction, loss, or insufficient mass of β cells. The main function of β cells is to produce and secrete insulin, the hormone responsible for the regulation of blood glucose levels. Type 1 diabetes (T1D) results from autoimmune destruction of β cells, while type 2 diabetes (T2D) mostly results from β-cell dysfunction or peripheral tissue resistance to insulin, often culminating in β-cell death. Thus, both forms of diabetes can benefit from restoration of β-cell mass. Currently, islet transplantation is the only way to provide new β cells to diabetic patients, but the scarcity of compatible cadaveric donors makes this approach available to only few patients; moreover, it requires lifelong immune suppression. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13073-017-0437-x |
It is part of: | Genome Medicine, 2017, vol. 9, p. 42 |
URI: | http://hdl.handle.net/2445/172610 |
Related resource: | https://doi.org/10.1186/s13073-017-0437-x |
ISSN: | 1756-994X |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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697647.pdf | 474.11 kB | Adobe PDF | View/Open | |
697647_Erratum.pdf | 221.62 kB | Adobe PDF | View/Open |
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