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http://hdl.handle.net/2445/172745
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DC Field | Value | Language |
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dc.contributor.author | Rodríguez García, José A. | - |
dc.contributor.author | Caballero García, María Dolores | - |
dc.contributor.author | Gutiérrez, Antonio | - |
dc.contributor.author | Gandarillas, Marco | - |
dc.contributor.author | Sierra Gil, Jorge | - |
dc.contributor.author | López Guillermo, Armando | - |
dc.contributor.author | Zuazu, Javier | - |
dc.contributor.author | Marín Solano, Jesús | - |
dc.contributor.author | Arranz, Reyes | - |
dc.contributor.author | Carreras Gómez, Enric | - |
dc.contributor.author | León, Ángel | - |
dc.contributor.author | Fernández de Sevilla Ribosa, Alberto | - |
dc.contributor.author | San Miguel, Jesús F. | - |
dc.contributor.author | Conde, Eulogio | - |
dc.contributor.author | GEL/TAMO Spanish Group | - |
dc.date.accessioned | 2020-12-15T13:48:46Z | - |
dc.date.available | 2020-12-15T13:48:46Z | - |
dc.date.issued | 2003-12-01 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172745 | - |
dc.description.abstract | Background and objectives: patients with aggressive non-Hodgkin's lymphomas (NHL) who do not obtain a complete response (CR) after induction chemotherapy have a poor prognosis. However, provided they are sensitive to the first regimen of chemotherapy, 25-40% of them with a B-cell phenotype may achieve long-term survival when treated with high dose chemotherapy and autologous stem cell transplantation (HDC/ASCT). The aim of this study was to analyze the efficacy of this therapy in the corresponding patients with peripheral T-cell lymphoma (PTCL). Design and methods: we retrospectively evaluated the efficacy of ASCT in 35 patients with PTCL from the GEL-TAMO registry, who did not achieve a CR to standard induction chemotherapy regimens for aggressive NHL. Thirty-one patients underwent transplantation after achieving a partial response (PR) and 4 patients were non-responders. Results: following HDC/ASCT, 23 (66%) of the patients achieved a CR, 4 (11%) a PR and in 7 (20%) cases the transplant failed. One patient was not evaluated because of early toxic death. With a median follow-up of the survivors of 37.5 months, 18 patients (51%) are alive and 15 patients (43%) are free of disease. Transplant-related mortality rate at 100 days was 11% and at 5 years the probabilities of survival, freedom from progression and disease-free survival for complete responders were 37%, 36% and 55% respectively. Pre-transplant lactate-dehydrogenase level, age-adjusted International Prognostic Index (aa-IPI) and tumor score correlated with survival. Interpretation and conclusions: one third of the patients with PTCL who fail to achieve CR to the first chemotherapeutic regimen can be rescued with HDC/ASCT. Pre-transplant values of IPI and tumor score risk systems for aggressive lymphomas were useful to predict subsequent survival. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://haematologica.org/issue/view/112 | - |
dc.relation.ispartof | Haematologica, 2003, vol. 88, num. 12, p. 1372-1377 | - |
dc.rights | (c) Ferrata Storti Foundation, 2003 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Ús terapèutic | - |
dc.subject.classification | Limfomes | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.other | Therapeutic use | - |
dc.subject.other | Lymphomas | - |
dc.subject.other | T cells | - |
dc.subject.other | Stem cells | - |
dc.title | High dose chemotherapy and autologous stem cell transplantation in patients with peripheral T-cell lymphoma not achieving complete response after induction chemotherapy. The GEL-TAMO experience | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 519009 | - |
dc.date.updated | 2020-12-15T13:48:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 14687990 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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519009.pdf | 108.75 kB | Adobe PDF | View/Open |
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