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Title: | Defining the role of neutrophil-to-lymphocyte ratio in COPD: a systematic literature review |
Author: | Pascual-González, Yuliana López Sánchez, Marta Dorca i Sargatal, Jordi Santos Pérez, Salud |
Keywords: | Malalties pulmonars obstructives cròniques Mortalitat Chronic obstructive pulmonary diseases Mortality |
Issue Date: | 1-Jan-2018 |
Publisher: | Dove Medical Press Ltd. |
Abstract: | COPD is characterized by a pulmonary and systemic inflammatory process. Several authors have reported the elevation of multiple inflammatory markers in patients with COPD; however, their use in routine clinical practice has limitations. The neutrophil-to-lymphocyte ratio (NLR) is a useful and cost-effective inflammatory marker derived from routine complete blood count. We performed a systematic literature review using the PRISMA statement. Twenty-two articles were included, recruiting 7,601 COPD patients and 784 healthy controls. Compared with controls, COPD patients had significantly higher NLR values. We found a significant correlation between the NLR and clinical/functional parameters (FEV1, mMRC, and BODE index) in COPD patients. Elevation of the NLR is associated with the diagnosis of acute exacerbation of COPD (pooled data propose a cut-off value of 3.34 with a median sensitivity, specificity, and area under the curve of 80%, 86%, and 0.86, respectively). Additionally, increased NLR is also associated with the diagnosis of a bacterial infection in exacerbated patients, with a cut-off value of 7.30, although with a low sensitivity and specificity. The NLR is an independent predictor of in-hospital and late mortality after exacerbation. In conclusion, the NLR could be a useful marker in COPD patients; however, further studies are needed to better identify the clinical value of the NLR. |
Note: | Reproducció del document publicat a: https://doi.org/10.2147/COPD.S178068 |
It is part of: | International Journal of Chronic Obstructive Pulmonary Disease, 2018, vol. 13, p. 3651-3662 |
URI: | http://hdl.handle.net/2445/172750 |
Related resource: | https://doi.org/10.2147/COPD.S178068 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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