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http://hdl.handle.net/2445/172779
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DC Field | Value | Language |
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dc.contributor.author | Méndez-Lara, Karen Alejandra | - |
dc.contributor.author | Letelier Torres, Nicole | - |
dc.contributor.author | Farré, Núria | - |
dc.contributor.author | Diarte-Añazco, Elena M.G. | - |
dc.contributor.author | Nieto-Nicolau, Nuria | - |
dc.contributor.author | Rodríguez-Millán, Elisabeth | - |
dc.contributor.author | Santos, David | - |
dc.contributor.author | Pallarès, Víctor | - |
dc.contributor.author | Escolà Gil, Joan Carles | - |
dc.contributor.author | Vázquez Del Olmo, Tania | - |
dc.contributor.author | Lerma, Enrique | - |
dc.contributor.author | Camacho, Mercedes | - |
dc.contributor.author | Casaroli Marano, Ricardo Pedro | - |
dc.contributor.author | Valledor Fernández, Annabel | - |
dc.contributor.author | Blanco-Vaca, Francisco | - |
dc.contributor.author | Julve, Josep | - |
dc.date.accessioned | 2020-12-16T14:15:53Z | - |
dc.date.available | 2020-12-16T14:15:53Z | - |
dc.date.issued | 2020-11-21 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172779 | - |
dc.description.abstract | The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic atherosclerosis was significantly reduced (NAM low dose: 45%; NAM high dose: 55%) in NAM-treated, apolipoprotein (Apo)E-deficient mice challenged with a Western diet for 4 weeks. NAM administration significantly increased (1.8-fold) the plasma concentration of proatherogenic ApoB-containing lipoproteins in NAM high-dose (HD)-treated mice compared with untreated mice. However, isolated ApoB-containing lipoproteins from NAM HD mice were less prone to oxidation than those of untreated mice. This result was consistent with the decreased (1.5-fold) concentration of oxidized low-density lipoproteins in this group. Immunohistochemical staining of aortas from NAM-treated mice showed significantly increased levels of IL-10 (NAM low-dose (LD): 1.3-fold; NAM HD: 1.2-fold), concomitant with a significant decrease in the relative expression of TNFα (NAM LD: −44%; NAM HD: −57%). An improved anti-inflammatory pattern was reproduced in macrophages cultured in the presence of NAM. Thus, dietary NAM supplementation in ApoE-deficient mice prevented the development of atherosclerosis and improved protection against ApoB-containing lipoprotein oxidation and aortic inflammation. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/antiox9111162 | - |
dc.relation.ispartof | Antioxidants, 2020, vol. 9, num. 11, p. 1162 | - |
dc.relation.uri | https://doi.org/10.3390/antiox9111162 | - |
dc.rights | cc-by (c) Méndez-Lara, Karen Alejandra et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Aterosclerosi | - |
dc.subject.classification | Vitamines B | - |
dc.subject.classification | Assaigs clínics de medicaments | - |
dc.subject.other | Atherosclerosis | - |
dc.subject.other | Vitamin B complex | - |
dc.subject.other | Drug testing | - |
dc.title | Nicotinamide Prevents apolipoprotein b-containing lipoprotein oxidation, inflammation and atherosclerosis in apolipoprotein e-deficient mice | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 705316 | - |
dc.date.updated | 2020-12-16T14:15:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33233455 | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
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705316.pdf | 4.56 MB | Adobe PDF | View/Open |
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