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Title: Prevalence of sleep disorders in adults with down syndrome: a comparative study of subjective, actigraphic and polygraphic findings
Author: Giménez, Sandra
Videla, Laura
Romero, Sergio
Benejam, Bessy
Clos, Susana
Fernández, Susana
Martínez, Maribel
Carmona-Iragui, Maria
Antonijoan Arbós, Rosa Ma. (Rosa María)
Mayos, Mercedes
Fortuna, Ana
Peñacoba, Patricia
Plaza, Vicente
Osorio, Ricardo S.
Sharma, Ram A.
Bardés, Ignasi
Rebillat, Anne Sophie
Lleó Bisa, Alberto
Blesa González, Rafael
Videla, Sebas
Fortea Ormaechea, Juan
Keywords: Síndrome de Down
Trastorns del son
Down syndrome
Sleep disorders
Issue Date: 2018
Publisher: American Academy of Sleep Medicine
Abstract: STUDY OBJECTIVES:Sleep problems are often undetected in adults with Down syndrome (DS). Our objective was to determine the prevalence of sleep disorders in adults with DS through self-reported and objective sleep measures. METHODS:We performed a community-based cross-sectional study of 54 adults with DS not referred for sleep disorders. Two polysomnography (PSG) sleep studies were performed. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI); daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS) and the risk for the sleep apnea syndrome (OSA) was identified using the Berlin Questionnaire (BQ). Participants' sleep/wake pattern was assessed from sleep diaries and by wrist actigraphy. PSQI, ESS, and PSG measures were compared with 35 sex-, age-, and body mass index-matched patients in the control groups. RESULTS:In PSG measures, adults with DS showed lower sleep efficiency (69 ± 17.7 versus 81.6 ± 11; P < .001), less rapid eye movement sleep (9.4 ± 5.8 versus 19.4 ± 5.1; P < .001), a higher prevalence of OSA (78% versus 14%; P < .001), and a higher apnea-hypopnea index (23.5 ± 24.5 versus 3.8 ± 10.5; P < .001) than patients in the control group. In the DS group, the questionnaires (mean PSQI 3.7 ± 2.9; mean ESS 6.3 ± 4.5 and mean BQ 1 ± 0) did not reflect the sleep disturbances detected on the PSG. Actigraphy data recorded daytime sleep that was not self-reported (118.2 ± 104.2 minutes). CONCLUSIONS:Adults with DS show severe sleep disruption and a high prevalence of OSA, undetected by self-reported sleep measures. Actigraphy, PSG, and validated simplified devices for screening OSA should be routinely recommended for this population because treatment of sleep disorders can contribute to healthy aging.
Note: Versió postprint del document publicat a:
It is part of: Journal of Clinical Sleep Medicine, 2018, vol. 14, num. 10, p. 1725-1733
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ISSN: 1550-9389
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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