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http://hdl.handle.net/2445/172844
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DC Field | Value | Language |
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dc.contributor.author | Stein, Heike | - |
dc.contributor.author | Barbosa, João Moura | - |
dc.contributor.author | Rosa Justicia, Mireia | - |
dc.contributor.author | Prades, Laia | - |
dc.contributor.author | Morató, Alba | - |
dc.contributor.author | Galan-Gadea, Adria | - |
dc.contributor.author | Ariño Rodríguez, Helena | - |
dc.contributor.author | Martínez Hernández, Eugenia | - |
dc.contributor.author | Castro Fornieles, Josefina | - |
dc.contributor.author | Dalmau Obrador, Josep | - |
dc.contributor.author | Compte Braquets, Albert | - |
dc.date.accessioned | 2020-12-17T15:45:21Z | - |
dc.date.available | 2020-12-17T15:45:21Z | - |
dc.date.issued | 2020-08-25 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172844 | - |
dc.description.abstract | A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account of two symptomatologically related diseases, both linked to hypofunctional NMDARs: schizophrenia and autoimmune anti-NMDAR encephalitis. We first quantified shared working memory alterations in a delayed-response task. In both patient groups, we report a markedly reduced influence of previous stimuli on working memory contents, despite preserved memory precision. We then simulated this finding with NMDAR-dependent synaptic alterations in a microcircuit model of prefrontal cortex. Changes in cortical excitation destabilized within-trial memory maintenance and could not account for disrupted serial dependence in working memory. Rather, a quantitative fit between data and simulations supports alterations of an NMDAR-dependent memory mechanism operating on longer timescales, such as short-term potentiation. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-18033-3 | - |
dc.relation.ispartof | Nature Communications, 2020, vol. 11, num. 1, p. 4250 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-020-18033-3 | - |
dc.rights | cc-by (c) Stein, Heike et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Memòria | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.classification | Encefalitis | - |
dc.subject.other | Memory | - |
dc.subject.other | Schizophrenia | - |
dc.subject.other | Encephalitis | - |
dc.title | Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 705301 | - |
dc.date.updated | 2020-12-17T15:45:21Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/713673/EU//INPhINIT | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 7980063 | - |
dc.identifier.pmid | 32843635 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
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File | Description | Size | Format | |
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705301.pdf | 1.42 MB | Adobe PDF | View/Open |
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