Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/172848
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bellomo, Claudia | - |
dc.contributor.author | Caja Puigsubirà, Laia | - |
dc.contributor.author | Fabregat Romero, Isabel | - |
dc.contributor.author | Mikulits, Wolfgang | - |
dc.contributor.author | Kardassis, Dimitris | - |
dc.contributor.author | Heldin, Carl-Henrik | - |
dc.contributor.author | Moustakas, Aristidis | - |
dc.date.accessioned | 2020-12-17T16:02:58Z | - |
dc.date.available | 2020-12-17T16:02:58Z | - |
dc.date.issued | 2017-12-11 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172848 | - |
dc.description.abstract | Understanding the complexity of changes in differentiation and cell survival in hepatocellular carcinoma (HCC) is essential for the design of new diagnostic tools and therapeutic modalities. In this context, we have analyzed the crosstalk between transforming growth factor β (TGFβ) and liver X receptor α (LXRα) pathways. TGFβ is known to promote cytostatic and pro-apoptotic responses in HCC, and to facilitate mesenchymal differentiation. We here demonstrate that stimulation of the nuclear LXRα receptor system by physiological and clinically useful agonists controls the HCC response to TGFβ. Specifically, LXRα activation antagonizes the mesenchymal, reactive oxygen species and pro-apoptotic responses to TGFβ and the mesenchymal transcription factor Snail mediates this crosstalk. In contrast, LXRα activation and TGFβ cooperate in enforcing cytostasis in HCC, which preserves their epithelial features. LXRα influences Snail expression transcriptionally, acting on the Snail promoter. These findings propose that clinically used LXR agonists may find further application to the treatment of aggressive, mesenchymal HCCs, whose progression is chronically dependent on autocrine or paracrine TGFβ. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41418-017-0021-3 | - |
dc.relation.ispartof | Cell Death and Differentiation, 2017 | - |
dc.relation.uri | https://doi.org/10.1038/s41418-017-0021-3 | - |
dc.rights | cc by-nc-nd (c) Bellomo et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Càncer de fetge | - |
dc.subject.classification | Terapèutica | - |
dc.subject.other | Liver cancer | - |
dc.subject.other | Therapeutics | - |
dc.title | Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 676666 | - |
dc.date.updated | 2020-12-17T16:02:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29230000 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
676666.pdf | 5.37 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License