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http://hdl.handle.net/2445/172893
Title: | Fibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Mice |
Author: | Aso Pérez, Ester Serrano, Antonio L. Muñoz Cánoves, Pura, 1962- Ferrer, Isidro (Ferrer Abizanda) |
Keywords: | Ratolins (Animals de laboratori) Malaltia d'Alzheimer Amiloïdosi Fibrinogen Inflamació Mice (Laboratory animals) Alzheimer's disease Amyloidosis Fibrinogen Inflammation |
Issue Date: | 21-Apr-2015 |
Publisher: | IOS Press |
Abstract: | Fibrinogen has emerged as a promising therapeutic target against Alzheimer's disease because of its dual role in altered vascular function and amyloid-β aggregation. Here we provide evidence regarding cognitive improvement and reduction of brain parenchyma amyloid-β deposition in AβPP/PS1 mice after treatment for one month with the fibrinogen-blocking peptide Fibγ377-395. No alteration in glial response or other neuroinflammatory markers was observed in the cortex of treated animals. Considering these results and the fact that Fibγ377-395 does not affect coagulation function, this peptide could be considered as a promising and safe candidate for chronic treatment of Alzheimer's disease. |
Note: | Reproducció del document publicat a: https://doi.org/10.3233/JAD-142928 |
It is part of: | Journal of Alzheimer's Disease, 2015, vol. 47, num. 2, p. 403-412 |
URI: | http://hdl.handle.net/2445/172893 |
Related resource: | https://doi.org/10.3233/JAD-142928 |
ISSN: | 1387-2877 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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