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Title: Neuronal haemoglobin is reduced in alzheimer's disease, argyrophilic grain disease, parkinson's disease, and dementia with lewy bodies
Author: Ferrer, Isidro (Ferrer Abizanda)
Gómez, Ana
Carmona Murillo, Margarita
Huesa, Gema
Porta, Sílvia
Riera i Codina, Miquel
Biagioli, Marta
Gustincich, Stefano
Aso Pérez, Ester
Keywords: Malaltia d'Alzheimer
Demència amb cossos de Lewy
Malaltia de Parkinson
Alzheimer's disease
Lewy body dementia
Parkinson's disease
Issue Date: 1-Jan-2011
Publisher: IOS Press
Abstract: Previous studies have demonstrated the presence of hemoglobin α-chain and β-chain in neurons of the rodent and human brain thus indicating that hemoglobin is a normal component of nerve cells and that hemoglobin may play a role in intraneuronal oxygen homeostasis. Progressing with these studies, hemoglobin expression has been examined in selected cell population in the brains of Alzheimer's disease (AD), argyrophilic grain disease (AGD), Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). Double labeling immunofluorescence and confocal microscopy revealed reduced hemoglobin α-chain and β-chain in practically all neurons with small amounts of granular or punctuate hyperphosphorylated tau deposits and in neurons with tangles in the hippocampus and frontal cortex in AD and in the hippocampus in AGD; in ballooned neurons containing αB-crystallin in the amygdala in AD and AGD; and in about 80% of neurons with punctuate α-synuclein deposits and in neurons with Lewy bodies in the substantia nigra pars compacta and in vulnerable neurons of the medulla oblongata in PD and DLB; and in neurons with Lewy bodies in the frontal cortex in DLB. Hemoglobin immunoreactivity was also observed in the core of neuritic plaques and in diffuse plaques, but not in dystrophic neurites. Loss of hemoglobin was specific as neuroglobin was present equally in neurons with and without abnormal protein inclusions, and erythropoietin receptor was expressed equally in neurons without and in neurons with abnormal protein aggregates in AD, AGD, PD, and DLB.
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It is part of: Journal of Alzheimer's Disease, 2011, vol. 23, num. 3, p. 537-550
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ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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