Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/173024
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Garreta, Elena | - |
dc.contributor.author | Kamm, Roger D. | - |
dc.contributor.author | Chuva de Sousa Lopes, Susana M. | - |
dc.contributor.author | Lancaster, Madeline A. | - |
dc.contributor.author | Weiss, Ron | - |
dc.contributor.author | Trepat Guixer, Xavier | - |
dc.contributor.author | Hyun, Insoo | - |
dc.contributor.author | Montserrat, Núria | - |
dc.date.accessioned | 2021-01-08T18:38:08Z | - |
dc.date.available | 2021-05-16T05:10:23Z | - |
dc.date.issued | 2020-11-16 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173024 | - |
dc.description.abstract | In recent years considerable progress has been made in the development of faithful procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step in this direction has also been the derivation of organoids. This technology generally relies on traditional three-dimensional culture techniques that exploit cell-autonomous self-organization responses of hPSCs with minimal control over the external inputs supplied to the system. The convergence of stem cell biology and bioengineering offers the possibility to provide these stimuli in a controlled fashion, resulting in the development of naturally inspired approaches to overcome major limitations of this nascent technology. Based on the current developments, we emphasize the achievements and ongoing challenges of bringing together hPSC organoid differentiation, bioengineering and ethics. This Review underlines the need for providing engineering solutions to gain control of self-organization and functionality of hPSC-derived organoids. We expect that this knowledge will guide the community to generate higher-grade hPSC-derived organoids for further applications in developmental biology, drug screening, disease modelling and personalized medicine. | ca |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/s41563-020-00804-4 | - |
dc.relation.ispartof | Nature Materials, 2020, p. 145-155 | - |
dc.relation.uri | https://doi.org/10.1038/s41563-020-00804-4 | - |
dc.rights | (c) Springer Nature Limited, 2020 | - |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.classification | Bioenginyeria | - |
dc.subject.other | Stem cells | - |
dc.subject.other | Bioengineering | - |
dc.title | Rethinking organoid technology through bioengineering | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/640525/EU//REGMAMKID | ca |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/616480 /EU//TensionControl | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/725722/EU//OVO-GROWTH | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/757710/EU//CerebralHominoids | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33199860 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
L20_2020_Nature Materials_X_X_OA.pdf | 3.03 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.