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Title: Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
Author: Heath, Alicia K.
Muller, David C.
van den Brandt, Piet A.
Papadimitriou, Nikos
Critselis, Elena
Gunter, Marc
Vineis, Paolo
Weiderpass, Elisabete
Fagherazzi, Guy
Boeing, Heiner
Ferrari, Pietro
Olsen, Anja
Tjønneland, Anne
Arveux, Patrick
Boutron-Ruault, Marie-Christine
Mancini, Francesca Romana
Kühn, Tilman
Turzanski Fortner, Renée
Schulze, Matthias B.
Karakatsani, Anna
Thriskos, Paschalis
Trichopoulou, Antonia
Masala, Giovanna
Contiero, Paolo
Ricceri, Fulvio
Panico, Salvatore
Bueno de Mesquita, H. Bas
Bakker, Marije F.
van Gils, Carla H.
Olsen, Karina Standahl
Skeie, Guri
Lasheras, Cristina
Agudo, Antonio
Rodríguez Barranco, Miguel
Sánchez, Maria José
Amiano, Pilar
Chirlaque, María Dolores
Barricarte, Aurelio
Drake, Isabel
Ericson, Ulrika
Johansson, Ingegerd
Winkvist, Anna
Key, Tim
Freisling, Heinz
His, Mathilde
Huybrechts, Inge
Christakoudi, Sofia
Ellingjord-Dale, Merete
Riboli, Elio
Tsilidis, Konstantinos K.
Tzoulaki, Ioanna
Keywords: Càncer de mama
Breast cancer
Issue Date: 13-Jan-2020
Publisher: BioMed Central
Abstract: Background: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Methods: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Results: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03–1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03–1.06 and 1.04, 95% CI 1.02–1.06, respectively), whereas higher intakes of fibre, apple/ pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94–0.98; 0.96, 95% CI 0.94–0.99; and 0.96, 95% CI 0.95–0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. Conclusions: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
Note: Reproducció del document publicat a:
It is part of: Breast Cancer Research, 2020, vol. 22, num. 5
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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