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http://hdl.handle.net/2445/173078
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DC Field | Value | Language |
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dc.contributor.author | Sánchez, Ricardo | - |
dc.contributor.author | Ribera, Jordi | - |
dc.contributor.author | Morgades, Mireia | - |
dc.contributor.author | Ayala, Rosa | - |
dc.contributor.author | Onecha, Esther | - |
dc.contributor.author | Ruiz Heredia, Yanira | - |
dc.contributor.author | Juárez Rufián, Alexandra | - |
dc.contributor.author | Nicolás, Rodrigo de | - |
dc.contributor.author | Sánchez Pina, José | - |
dc.contributor.author | Vives, Susana | - |
dc.contributor.author | Zamora, Lurdes | - |
dc.contributor.author | Mercadal, Santiago | - |
dc.contributor.author | Coll, Rosa | - |
dc.contributor.author | Cervera, Marta | - |
dc.contributor.author | Garcia, Olga | - |
dc.contributor.author | Ribera, Josep Maria | - |
dc.contributor.author | Martínez López, Joaquín | - |
dc.date.accessioned | 2021-01-12T19:05:31Z | - |
dc.date.available | 2021-01-12T19:05:31Z | - |
dc.date.issued | 2020-04-24 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173078 | - |
dc.description.abstract | BCR-ABL1-like B-cell precursor acute lymphoblastic leukemia (BCP-ALL) remains poorly characterized in adults. We sought to establish the frequency and outcome of adolescent and adult BCR-ABL1-like ALL using a novel RNA-Seq signature in a series of patients with BCP-ALL. To this end, we developed and tested an RNA-Seq custom panel of 42 genes related to a BCR-ABL1-like signature in a cohort of 100 patients with BCP-ALL and treated with risk-adapted ALL trials. Mutations related to BCR-ABL1-like ALL were studied in a panel of 33 genes by next-generation sequencing (NGS). Also, CRLF2 overexpression and IKZF1/CDKN2A/B deletions were analyzed. Twenty out of 79 patients (12-84 years) were classified as BCR-ABL1-like (25%) based on heatmap clustering, with significant overexpression of ENAM, IGJ, and CRLF2 (P <= 0.001). The BCR-ABL1-like subgroup accounted for 29% of 15-60-year-old patients, with the following molecular characteristics: CRLF2 overexpression (75% of cases), IKZF1 deletions (64%), CDKN2A/B deletions (57%), and JAK2 mutations (57%). Among patients with postinduction negative minimal residual disease, those with the BCR-ABL1-like ALL signature had a higher rate of relapse and lower complete response duration than non-BCR-ABL1-like patients (P = 0.007). Thus, we have identified a new molecular signature of BCR-ABL1-like ALL that correlates with adverse prognosis in adult patients with ALL. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41408-020-0308-3 | - |
dc.relation.ispartof | Blood Cancer Journal, 2020, vol. 10, num. 4 | - |
dc.relation.uri | https://doi.org/10.1038/s41408-020-0308-3 | - |
dc.rights | cc by (c) Sánchez et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Prognosis | - |
dc.title | A novel targeted RNA-Seq panel identifies a subset of adult patients with acute lymphoblastic leukemia with BCR-ABL1-like characteristics | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-12-21T13:10:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32332702 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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SanchezR.pdf | 1.33 MB | Adobe PDF | View/Open |
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