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http://hdl.handle.net/2445/173157
Title: | Psychosocial stress and epigenetic aging |
Author: | Palma-Gudiel, Helena Fañanás Saura, Lourdes Horvath, Steve Zannas, Anthony S. |
Keywords: | Envelliment Estrès Epigenètica Aging Stress Epigenetics |
Issue Date: | 20-Nov-2019 |
Publisher: | Elsevier |
Abstract: | Aging is the single most important risk factor for diseases that are currently the leading causes of morbidity and mortality. However, there is considerable inter-individual variability in risk for aging-related disease, and studies suggest that biological age can be influenced by multiple factors, including exposure to psychosocial stress. Among markers of biological age that can be affected by stress, the present article focuses on the so-called measures of epigenetic aging: DNA methylation-based age predictors that are measured in a range of tissues, including the brain, and can predict lifespan and healthspan. We review evidence linking exposure to diverse types of psychosocial stress, including early-life stress, cumulative stressful experiences, and low socioeconomic status, with accelerated epigenetic aging as a putative mediator of the effects of psychosocial environment on health and disease. The chapter also discusses methodological |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/bs.irn.2019.10.020 |
It is part of: | International Review of Neurobiology, 2019, vol. 150, p. 107-128 |
URI: | http://hdl.handle.net/2445/173157 |
Related resource: | https://doi.org/10.1016/bs.irn.2019.10.020 |
ISSN: | 0074-7742 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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