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http://hdl.handle.net/2445/173235
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DC Field | Value | Language |
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dc.contributor.author | López Mejías, Raquel | - |
dc.contributor.author | Remuzgo Martínez, Sara | - |
dc.contributor.author | Genre, Fernanda | - |
dc.contributor.author | Pulito Cueto, Verónica | - |
dc.contributor.author | Fernández Rozas, Sonia M. | - |
dc.contributor.author | Llorca, Javier | - |
dc.contributor.author | Iturbe Fernandez, David | - |
dc.contributor.author | Mora Cuesta, Víctor M. | - |
dc.contributor.author | Ortego Centeno, Norberto | - |
dc.contributor.author | Pérez Gómez, Norberto | - |
dc.contributor.author | Mera Varela, Antonio | - |
dc.contributor.author | Martínez Barrio, Julia | - |
dc.contributor.author | López Longo, Francisco J. | - |
dc.contributor.author | Mijares, Verónica | - |
dc.contributor.author | Lera Gómez, Leticia | - |
dc.contributor.author | Ussetti, María Piedad | - |
dc.contributor.author | Laporta, Rosalía | - |
dc.contributor.author | Pérez, Virginia | - |
dc.contributor.author | Pablo Gafas, Alicia de | - |
dc.contributor.author | Alfranca González, María Aránzazu | - |
dc.contributor.author | Calvo Alén, Jaime | - |
dc.contributor.author | Romero Bueno, Fredeswinda | - |
dc.contributor.author | Sánchez Pernaute, Olga | - |
dc.contributor.author | Nuno, Laura | - |
dc.contributor.author | Bonilla, Gema | - |
dc.contributor.author | Balsa, Alejandro | - |
dc.contributor.author | Hernández González, Fernanda | - |
dc.contributor.author | Grafia, Ignacio | - |
dc.contributor.author | Prieto González, Sergio | - |
dc.contributor.author | Narváez García, Francisco Javier | - |
dc.contributor.author | Trallero Araguas, Ernesto | - |
dc.contributor.author | Selva O'Callaghan, Albert | - |
dc.contributor.author | Gualillo, Oreste | - |
dc.contributor.author | Castañeda, Santos | - |
dc.contributor.author | Cavagna, Lorenzo | - |
dc.contributor.author | Cifrian, José M. | - |
dc.contributor.author | González Gay, Miguel A. | - |
dc.date.accessioned | 2021-01-20T08:25:26Z | - |
dc.date.available | 2021-01-20T08:25:26Z | - |
dc.date.issued | 2020-01-29 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173235 | - |
dc.description.abstract | MUC5B rs35705950 (G/T) is strongly associated with idiopathic pulmonary fibrosis (IPF) and also contributes to the risk of interstitial lung disease (ILD) in rheumatoid arthritis (RA-ILD) and chronic hypersensitivity pneumonitis (CHP). Due to this, we evaluated the implication of MUC5B rs35705950 in antisynthetase syndrome (ASSD), a pathology characterised by a high ILD incidence. 160 patients with ASSD (142 with ILD associated with ASSD [ASSD-ILD+]), 232 with ILD unrelated to ASSD (comprising 161 IPF, 27 RA-ILD and 44 CHP) and 534 healthy controls were genotyped. MUC5B rs35705950 frequency did not significantly differ between ASSD-ILD+ patients and healthy controls nor when ASSD patients were stratified according to the presence/absence of anti Jo-1 antibodies or ILD. No significant differences in MUC5B rs35705950 were also observed in ASSD-ILD+ patients with a usual interstitial pneumonia (UIP) pattern when compared to those with a non-UIP pattern. However, a statistically significant decrease of MUC5B rs35705950 GT, TT and T frequencies in ASSD-ILD+ patients compared to patients with ILD unrelated to ASSD was observed. In summary, our study does not support a role of MUC5B rs35705950 in ASSD. It also indicates that there are genetic differences between ILD associated with and that unrelated to ASSD. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-58400-0 | - |
dc.relation.ispartof | Scientific Reports, 2020, vol. 10 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-020-58400-0 | - |
dc.rights | cc by (c) López Mejías et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Fibrosi pulmonar | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Pulmonary fibrosis | - |
dc.title | Influence of MUC5B gene on antisynthetase syndrome | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-12-21T13:16:34Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/734899/EU//Olive-Net | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31996780 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Lopez-MejiasR.pdf | 1.04 MB | Adobe PDF | View/Open |
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