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Title: | Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts |
Author: | Bassetti, Matteo Vena, Antonio Meroi, Marco Cardozo Espinola, Celia Cuervo Requena, Guillermo Giacobbe, Daniele Roberto Salavert, Miguel Merino, Paloma Gioia, Francesca Fernández Ruiz, Mario López Cortés, Luis Eduardo Almirante, Benito Escolà Vergé, Laura Montejo, Miguel Aguilar Guisado, Manuela Puerta-Alcalde, Pedro Tasias, Mariona Ruiz Gaitán, Alba González, Fernando Puig Asensio, Mireia Marco Reverté, Francesc Pemán, Javier Fortún, Jesús Aguado, José María Soriano Viladomiu, Alex Carratalà, Jordi Garcia Vidal, Carolina Valerio, Maricela Sartor, Assunta Bouza, Emilio Muñoz, Patricia |
Keywords: | Candidiasi Xoc sèptic Candidiasis Septic shock |
Issue Date: | 1-Jan-2020 |
Publisher: | BioMed Central |
Abstract: | Background: Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify variables associated with septic shock development in a large population of patients with candidemia. Methods: A post hoc analysis was performed on two prospective, multicenter cohort of patients with candidemia from 12 hospitals in Spain and Italy. All episodes occurring from September 2016 to February 2018 were analyzed to assess variables associated with septic shock development defined according to The Third International Consensus Definition for Sepsis and Septic Shock (Sepsis-3). Results: Of 317 candidemic patients, 99 (31.2%) presented septic shock attributable to candidemia. Multivariate logistic regression analysis identifies the following factors associated with septic shock development: age > 50 years (OR 2.57, 95% CI 1.03–6.41, p = 0.04), abdominal source of the infection (OR 2.18, 95% CI 1.04–4.55, p = 0.04), and admission to a general ward at the time of candidemia onset (OR 0.21, 95% CI, 0.12–0.44, p = 0.001). Septic shock development was independently associated with a greater risk of 30-day mortality (OR 2.14, 95% CI 1.08–4.24, p = 0.02). Conclusions: Age and abdominal source of the infection are the most important factors significantly associated with the development of septic shock in patients with candidemia. Our findings suggest that host factors and source of the infection may be more important for development of septic shock than intrinsic virulence factors of organisms. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13054-020-2793-y |
It is part of: | Critical Care, 2020, vol. 24 |
URI: | http://hdl.handle.net/2445/173255 |
Related resource: | https://doi.org/10.1186/s13054-020-2793-y |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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