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Title: | The impact of p16(ink4a) positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study |
Author: | Gensthaler, Lisa Joura, Elmar A. Alemany i Vilches, Laia Horvat, Reinhard Sanjosé Llongueras, Silvia de Pils, Sophie |
Keywords: | Papil·lomavirus Càncer ginecològic Pronòstic mèdic Papillomaviruses Gynecologic cancer Prognosis |
Issue Date: | 1-Mar-2020 |
Publisher: | Springer Heidelberg |
Abstract: | Purpose To evaluate HPV and p16(ink4a) status as prognostic factors in patients with invasive vulvar cancer. Methods Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16(ink4a) status were evaluated in the context of a global multicenter trial. Logistic regression models were performed to identify the impact of p16(ink4a) positivity. Results 135 patients were included in the analysis. 32 (23.7%) showed a p16(ink4a) expression of over 25%. Disease-free and disease-specific survival was longer in p16(ink4a) positive patients (23 vs. 10 months, p = 0.004, respectively, 29 vs. 21 months, p = 0.016). In multivariate analysis, p16(ink4a) positivity was an independent parameter for DFS (p = 0.025, HR: 2.120 (1.100-4.085)), but not for DSS (p = 0.926, HR: 1.029 (0.558-1.901), in contrast to age and tumor stage. Conclusions Age and tumor stage negatively affect survival. However, disease-free survival is significantly longer in patients with p16(ink4a) positive invasive vulvar cancer. |
Note: | Reproducció del document publicat a: https://doi.org/10.1007/s00404-020-05431-7 |
It is part of: | Archives of Gynecology and Obstetrics, 2020, vol. 301, num. 3, p. 753-759 |
URI: | http://hdl.handle.net/2445/173258 |
Related resource: | https://doi.org/10.1007/s00404-020-05431-7 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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