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Title: | Laparoscopy versus open adrenalectomy in patients with solid tumor metastases: results of a multicenter European study |
Author: | Moreno Llorente, Pablo Quintana Basarrate, Aitor de la Musholt, Thomas J. Paunovic, Ivan Puccini, Marco Vidal Pérez, Oscar Ortega, Joaquín Kraimps, Jean-Louis European Study Group for Metastatic Adrenalectomy |
Keywords: | Laparoscòpia Metàstasi Tumors Laparoscopy Metastasis Tumors |
Issue Date: | 1-Sep-2020 |
Publisher: | AME Publishing Company |
Abstract: | Background: The outcome of adrenalectomy carried out by laparoscopy or open surgery for solid tumor metastases was assessed. Methods: A total of 317 patients with histologically confirmed adrenal metastatic disease collected from 30 centres in Europe underwent adrenalectomy by laparoscopy (n=146) or open laparotomy (n=171). Differences between laparoscopic and open adrenalectomy were assessed by a single Cox analysis for both procedures. Results: The median overall survival was 24.0 [95% confidence interval (CI): 21.4-26.6] months for open adrenalectomy and 45.0 (95% CI: 22.6-67.4) for laparoscopic adrenalectomy (P=0.008). Survival rates were 68%, 49%, 35% and 29% at 1, 2, 3 and 5 years for open surgery vs. 88%, 62%, 52% and 46% for laparoscopy, respectively. In the subgroup of R0 resections, the difference in survival in favor of laparoscopy (median 46 vs. 27 months) was marginally significant (P=0.073). Renal cancer [hazard ratio (HR) 0.42; 95% CI: 0.23-0.76, P=0.005], surgery of the primary tumor (HR 0.33; 95% CI: 0.19-0.54), and use of chemotherapy (HR 0.62; 95% CI: 0.43-0.88) were associated with a better survival, whereas type of resection (R1/R2 vs. R0) was associated with a worse prognosis (HR 2.29; 95% CI: 1.52-3.44, P<0.001). Conclusions: Laparoscopic adrenalectomy patients showed a longer survival than open adrenalectomy individuals, as minimally invasive approach was attempted more common in less advanced disease which led to higher number of R0 resections. |
Note: | Reproducció del document publicat a: https://doi.org/10.21037/gs.2019.10.15 |
It is part of: | Gland Surgery, 2020, vol. 9, num. 2, p. 159-165 |
URI: | http://hdl.handle.net/2445/173321 |
Related resource: | https://doi.org/10.21037/gs.2019.10.15 |
ISSN: | 2227-684X |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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