Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/173408
Title: | Association of germline variation with the survival of women with BRCA1/2 pathogenic variants and breast cancer |
Author: | Lázaro García, Conxi SWE-BRCA Group |
Keywords: | Càncer de mama Etiologia Breast cancer Etiology |
Issue Date: | 10-Sep-2020 |
Publisher: | Nature Publishing Group |
Abstract: | Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology. We have studied survival associations of genetic variants in two etiologically unique groups of breast cancer patients, the carriers of germline pathogenic variants in BRCA1 or BRCA2 genes. We found that rs57025206 was significantly associated with the overall survival, predicting higher mortality of BRCA1 carrier patients with estrogen receptor-negative breast cancer, with a hazard ratio 4.37 (95% confidence interval 3.03-6.30, P=3.1x10(-9)). Multivariable analysis adjusted for tumor characteristics suggested that rs57025206 was an independent survival marker. In addition, our exploratory analyses suggest that the associations between genetic variants and breast cancer patient survival may depend on tumor biological subgroup and clinical patient characteristics. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41523-020-00185-6 |
It is part of: | npj Breast Cancer, 2020, vol. 6 |
URI: | http://hdl.handle.net/2445/173408 |
Related resource: | https://doi.org/10.1038/s41523-020-00185-6 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
MuranenTA.pdf | 1.69 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License