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Title: A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
Author: Christakoudi, Sofia
Tsilidis, Konstantinos K.
Muller, David C.
Freisling, Heinz
Weiderpass, Elisabete
Overvad, Kim
Soderberg, Stefan
Haggstrom, Christel
Pischon, Tobias
Dahm, Christina C.
Zhang, Jie
Tjønneland, Anne
Halkjær, Jytte
MacDonald, Conor
Boutron-Ruault, Marie-Christine
Mancini, Francesca Romana
Kühn, Tilman
Kaaks, Rudolf
Schulze, Matthias B.
Trichopoulou, Antonia
Karakatsani, Anna
Peppa, Eleni
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Sacerdote, Carlotta
Quirós, J. Ramón
Agudo, Antonio
Sánchez, María José
Cirera, Lluís
Barricarte, Aurelio
Amiano, Pilar
Memarian, Ensieh
Sonestedt, Emily
Bueno de Mesquita, H. Bas
May, Anne M.
Khaw, Kay‑Tee
Wareham, Nicholas J.
Tong, Tammy Y. N.
Huybrechts, Inge
Noh, Hwayoung
Aglago, Elom K.
Ellingjord-Dale, Merete
Ward, Heather A.
Aune, Dagfinn
Riboli, Elio
Keywords: Obesitat
Factors de risc en les malalties
Risk factors in diseases
Issue Date: 3-Sep-2020
Publisher: Nature Research
Abstract: Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI<greater than or equal to>30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
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It is part of: Scientific Reports, 2020, Vol. 10, num. 10, p. 14541
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Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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