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https://hdl.handle.net/2445/173423
Title: | A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort |
Author: | Christakoudi, Sofia Tsilidis, Konstantinos K. Muller, David C. Freisling, Heinz Weiderpass, Elisabete Overvad, Kim Soderberg, Stefan Haggstrom, Christel Pischon, Tobias Dahm, Christina C. Zhang, Jie Tjønneland, Anne Halkjær, Jytte MacDonald, Conor Boutron-Ruault, Marie-Christine Mancini, Francesca Romana Kühn, Tilman Kaaks, Rudolf Schulze, Matthias B. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Masala, Giovanna Pala, Valeria Panico, Salvatore Tumino, Rosario Sacerdote, Carlotta Quirós, José Ramón Agudo, Antonio Sánchez, María José Cirera, Lluís Barricarte, Aurelio Amiano, Pilar Memarian, Ensieh Sonestedt, Emily Bueno de Mesquita, H. Bas May, Anne M. Khaw, Kay‑Tee Wareham, Nicholas J. Tong, Tammy Y. N. Huybrechts, Inge Noh, Hwayoung Aglago, Elom K. Ellingjord-Dale, Merete Ward, Heather A. Aune, Dagfinn Riboli, Elio |
Keywords: | Obesitat Mortalitat Factors de risc en les malalties Obesity Mortality Risk factors in diseases |
Issue Date: | 3-Sep-2020 |
Publisher: | Nature Research |
Abstract: | Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI<greater than or equal to>30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-71302-5 |
It is part of: | Scientific Reports, 2020, Vol. 10, num. 10, p. 14541 |
URI: | https://hdl.handle.net/2445/173423 |
Related resource: | https://doi.org/10.1038/s41598-020-71302-5 |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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