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Title: The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries
Author: Tong, Tammy Y. N.
Appleby, Paul N.
Key, Timothy J.
Dahm, Christina C.
Overvad, Kim
Olsen, Anja
Tjønneland, Anne
Katzke, Verena
Kühn, Tilman
Boeing, Heiner
Karakatsani, Anna
Peppa, Eleni
Trichopoulou, Antonia
Weiderpass, Elisabete
Masala, Giovanna
Grioni, Sara
Panico, Salvatore
Tumino, Rosario
Boer, Jolanda M. A.
Verschuren, W. M. Monique
Quirós, J. Ramón
Agudo, Antonio
Rodríguez Barranco, Miguel
Imaz, Liher
Chirlaque, María Dolores
Moreno Iribas, Conchi
Engström, Gunnar
Sonestedt, Emily
Lind, Marcus
Otten, Julia
Khaw, Kay-Tee
Aune, Dagfinn
Riboli, Elio
Wareham, Nicholas J.
Imamura, Fumiaki
Forouhi, Nita G.
Angelantonio, Emanuele di
Wood, Angela M.
Butterworth, Adam S.
Pérez Cornago, Aurora
Keywords: Isquèmia
Fibra alimentària
Fiber in human nutrition
Issue Date: 21-Jul-2020
Publisher: Oxford University Press
Abstract: Aim: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200g/day higher intake, 0.87; 0.82-0.93, P-trend<0.001), dietary fibre (per 10g/day, 0.77; 0.69-0.86, P-trend<0.001), milk (per 200g/day, 0.95; 0.91-0.99, P-trend=0.02), yogurt (per 100g/day, 0.91; 0.85-0.97, P-trend=0.004), and cheese (per 30g/day, 0.88; 0.81-0.97, P-trend=0.008), while higher risk was observed with higher red meat consumption which attenuated when adjusted for the other statistically significant foods (per 50g/day, 1.07; 0.96-1.20, P-trend=0.20). For haemorrhagic stroke (1430 cases), higher risk was associated with higher egg consumption (per 20g/day, 1.25; 1.09-1.43, P-trend=0.002). Conclusion: Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately.
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It is part of: European Heart Journal, 2020, vol. 41, num. 28, P. 2632-2640
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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