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Title: Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development
Author: Hosnijeh, Fatemeh Saberi
Kolijn, Pieter M.
Casabonne, Delphine
Nieters, Alexandra
Solans, Marta
Naudin, Sabine
Ferrari, Pietro
McKay, James D.
Weiderpass, Elisabete
Perduca, Vittorio
Besson, Caroline
Mancini, Francesca Romana
Masala, Giovanna
Krogh, Vittorio
Ricceri, Fulvio
Huerta Castaño, José María
Petrova, Dafina
Sala Serra, Núria
Trichopoulou, Antonia
Karakatsani, Anna
Vecchia, Carlo La
Kaaks, Rudolf
Canzian, Federico
Aune, Dagfinn
Boeing, Heiner
Schulze, Matthias B.
Pérez Cornago, Aurora
Langerak, Anton W.
van der Velden, Vincent H. J.
Vermeulen, Roel
Keywords: Limfomes
Cèl·lules B
Sistema immunitari
Estils de vida
B cells
Immune system
Issue Date: 14-Aug-2020
Publisher: Nature Research
Abstract: Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case-control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2020, vol. 10
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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