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Title: | Transconjunctival sutureless vitrectomy with tissue plasminogen activator, gas and intravitreal bevacizumab in the management of predominantly hemorrhagic age-related macular degeneration |
Author: | Arias Barquet, Lluís Monés, Jordi |
Keywords: | Degeneració Activador del plasminogen Vitrectomia Degeneration Plasminogen activators Vitrectomy |
Issue Date: | 1-Feb-2010 |
Publisher: | Dove Medical Press |
Abstract: | Purpose: to determine the efficacy and safety of treating predominantly hemorrhagic age-related macular degeneration (AMD) with transconjunctival sutureless vitrectomy (TSV), tissue plasminogen activator (tPA), sulphur hexafluoride (SF6), and intravitreal bevacizumab. Methods: retrospective study, consecutive case series. Patients with acute hemorrhagic AMD treated with 25- or 23-gauge TSV, subretinal or intravitreal tPA, fluid-air-SF6 exchange and intravitreal injection of bevacizumab. All operations were performed within the first 5 days after the start of symptoms, which consisted of visual acuity (VA) loss and central scotoma. Results: fifteen eyes from 15 patients were included. The patients' mean age was 79.6 years, and the mean follow-up was 11.8 months. Five patients (33%) were receiving oral anticoagulant treatment. At baseline, the mean VA (logMAR values) was 1.5 (20/640 Snellen equivalent). At the last follow-up visit, the mean VA was 1.1 (20/250) (P < 0.0001; paired t-test). The submacular hemorrhage was successfully displaced in all the cases. Complications consisted of three cases of vitreous hemorrhage and a tear or the retinal pigment epithelium. Twelve cases (80%) did not require further treatment during the follow-up period. Conclusion: a surgical approach with 25- or 23-gauge TSV, tPA, SF6 and intravitreal bevacizumab is an efficacious and safe procedure in patients with hemorrhagic AMD. Early treatment is advisable for obtaining the optimal outcome. |
Note: | Reproducció del document publicat a: https://doi.org/10.2147/opth.s8635 |
It is part of: | Clinical Ophthalmology, 2010, vol. 18, num. 4, p. 67-72 |
URI: | http://hdl.handle.net/2445/173624 |
Related resource: | https://doi.org/10.2147/opth.s8635 |
ISSN: | 1177-5467 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
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