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http://hdl.handle.net/2445/173650
Title: | Genetic and Immune Changes Associated with Disease Progression under the Pressure of Oncolytic Therapy in A Neuroblastoma Outlier Patient |
Author: | Franco Luzón, Lidia García Mulero, Sandra Sanz Pamplona, Rebeca Melen, Gustavo Ruano, David Lassaletta, Álvaro Madero, Luís González Murillo, África Ramírez, Manuel |
Keywords: | Càncer en els infants Limfòcits Cancer in children Lymphocytes |
Issue Date: | 1-May-2020 |
Publisher: | MDPI |
Abstract: | Little is known about the effect of oncolytic adenovirotherapy on pediatric tumors. Here we present the clinical case of a refractory neuroblastoma that responded positively to Celyvir (ICOVIR-5 oncolytic adenovirus delivered by autologous mesenchymal stem cells) for several months. We analyzed samples during tumor evolution in order to identify molecular and mutational features that could explain the interactions between treatment and tumor and how the balance between both of them evolved. We identified a higher adaptive immune infiltration during stabilized disease compared to progression, and also a higher mutational rate and T-cell receptor (TCR) diversity during disease progression. Our results indicate an initial active role of the immune system controlling tumor growth during Celyvir therapy. The tumor eventually escaped from the control exerted by virotherapy through acquisition of resistance by the tumor microenvironment that exhausted the initial T cell response. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers12051104 |
It is part of: | Cancers, 2020, vol. 12, num. 5 |
URI: | http://hdl.handle.net/2445/173650 |
Related resource: | https://doi.org/10.3390/cancers12051104 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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