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http://hdl.handle.net/2445/173694
Title: | Central neurogenetic signatures of the visuomotor integration system |
Author: | Bueicheku, Elisenda Aznárez Sanado, Maite Diez, Ibai Oleire Uquillas, Federico d’ Ortiz Terán, Laura Qureshi, Abid Y. Suñol, Maria Basaia, Silvia Ortiz Terán, Elena Pastor, Maria A Sepulcre, Jorge |
Keywords: | Xarxes neuronals (Neurobiologia) Genètica Neural networks (Neurobiology) Genetics |
Issue Date: | 1-Jan-2020 |
Publisher: | National Academy of Sciences |
Abstract: | Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. We found the genetic expression of four genes-TBR1, SCN1A, MAGEL2, and CACNB4-to be prominently associated with visuomotor integrators in the human cortex. TBR1 gene transcripts, an ASD gene whose expression is related to neural development of the cortex and the hippocampus, showed a central spatial allocation within the VMI system. Our findings delineate gene expression traits underlying the VMI system in the human cortex, where specific genes, such as TBR1, are likely to play a central role in its neuronal organization, as well as on specific phenotypes of neurogenetic syndromes. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1073/pnas.1912429117 |
It is part of: | Proceedings of The National Academy of Sciences of The United States of America, 2020, vol. 117, num. 12, p. 6836-6843 |
URI: | http://hdl.handle.net/2445/173694 |
Related resource: | https://doi.org/10.1073/pnas.1912429117 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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BueichekuE.pdf | 1.25 MB | Adobe PDF | View/Open |
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