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http://hdl.handle.net/2445/173702
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DC Field | Value | Language |
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dc.contributor.author | Casanova, María José | - |
dc.contributor.author | Chaparro, María | - |
dc.contributor.author | Mínguez, Miguel | - |
dc.contributor.author | Ricart, Elena | - |
dc.contributor.author | Taxonera, Carlos | - |
dc.contributor.author | García López, Santiago | - |
dc.contributor.author | Guardiola, Jordi | - |
dc.contributor.author | López San Román, Antonio | - |
dc.contributor.author | Iglesias, Eva | - |
dc.contributor.author | Beltrán, Belén | - |
dc.contributor.author | Sicilia, Beatriz | - |
dc.contributor.author | Vera, María Isabel | - |
dc.contributor.author | Hinojosa, Joaquín | - |
dc.contributor.author | Riestra, Sabino | - |
dc.contributor.author | Domènech, Eugeni | - |
dc.contributor.author | Calvet, Xavier | - |
dc.contributor.author | Pérez Calle, José Lázaro | - |
dc.contributor.author | Martín Arranz, María Dolores | - |
dc.contributor.author | Aldeguer, Xavier | - |
dc.contributor.author | Rivero, Montserrat | - |
dc.contributor.author | Monfort, David | - |
dc.contributor.author | Barrio, Jesús | - |
dc.contributor.author | Esteve i Comas, Maria | - |
dc.contributor.author | Márquez, Lucía | - |
dc.contributor.author | Lorente, Rufo | - |
dc.contributor.author | García Planella, Esther | - |
dc.contributor.author | Castro, Luisa de | - |
dc.contributor.author | Bermejo, Fernando | - |
dc.contributor.author | Merino, Olga | - |
dc.contributor.author | Rodríguez Pérez, Antonio | - |
dc.contributor.author | Martínez Montiel, Pilar | - |
dc.contributor.author | Van Domselaar, Manuel | - |
dc.contributor.author | Alcaín, Guillermo | - |
dc.contributor.author | Domínguez Cajal, Manuel | - |
dc.contributor.author | Muñoz, Carmen | - |
dc.contributor.author | Gomollón, Fernando | - |
dc.contributor.author | Fernández Salazar, Luis | - |
dc.contributor.author | García Sepulcre, Mariana Fe | - |
dc.contributor.author | Rodríguez Lago, Iago | - |
dc.contributor.author | Gutiérrez, Ana | - |
dc.contributor.author | Argüelles Arias, Federico | - |
dc.contributor.author | Rodríguez, Cristina | - |
dc.contributor.author | Rodríguez, Gloria Esther | - |
dc.contributor.author | Bujanda, Luis | - |
dc.contributor.author | Llaó, Jordina | - |
dc.contributor.author | Varela, Pilar | - |
dc.contributor.author | Ramos, Laura | - |
dc.contributor.author | Huguet, José María | - |
dc.contributor.author | Almela, Pedro | - |
dc.contributor.author | Romero, Patricia | - |
dc.contributor.author | Navarro Llavat, Mercè | - |
dc.contributor.author | Abad, Águeda | - |
dc.contributor.author | Ramírez de la Piscina, Patricia | - |
dc.contributor.author | Lucendo, Alfredo J. | - |
dc.contributor.author | Sesé, Eva | - |
dc.contributor.author | Madrigal, Rosa Eva | - |
dc.contributor.author | Charro, Mara | - |
dc.contributor.author | García Herola, Antonio | - |
dc.contributor.author | Pajares, Ramón | - |
dc.contributor.author | Khorrami, Sam | - |
dc.contributor.author | Gisbert, Javier P. | - |
dc.date.accessioned | 2021-02-05T13:49:16Z | - |
dc.date.available | 2021-02-05T13:49:16Z | - |
dc.date.issued | 2019-08-29 | - |
dc.identifier.issn | 1078-0998 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173702 | - |
dc.description.abstract | Background: The effectiveness of the switch to another anti-tumor necrosis factor (anti-TNF) agent is not known. The aim of this study was to analyze the effectiveness and safety of treatment with a second and third anti-TNF drug after intolerance to or failure of a previous anti-TNF agent in inflammatory bowel disease (IBD) patients. Methods: We included patients diagnosed with IBD from the ENEIDA registry who received another anti-TNF after intolerance to or failure of a prior anti-TNF agent. Results: A total of 1122 patients were included. In the short term, remission was achieved in 55% of the patients with the second anti-TNF. The incidence of loss of response was 19% per patient-year with the second anti-TNF. Combination therapy (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.8-3; P < 0.0001) and ulcerative colitis vs Crohn's disease (HR, 1.6; 95% CI, 1.1-2.1; P = 0.005) were associated with a higher probability of loss of response. Fifteen percent of the patients had adverse events, and 10% had to discontinue the second anti-TNF. Of the 71 patients who received a third anti-TNF, 55% achieved remission. The incidence of loss of response was 22% per patient-year with a third anti-TNF. Adverse events occurred in 7 patients (11%), but only 1 stopped the drug. Conclusions: Approximately half of the patients who received a second anti-TNF achieved remission; nevertheless, a significant proportion of them subsequently lost response. Combination therapy and type of IBD were associated with loss of response. Remission was achieved in almost 50% of patients who received a third anti-TNF; nevertheless, a significant proportion of them subsequently lost response. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1093/ibd/izz192 | - |
dc.relation.ispartof | Inflammatory Bowel Diseases, 2019, vol. 26, num. 4, p. 606-616 | - |
dc.relation.uri | https://doi.org/10.1093/ibd/izz192 | - |
dc.rights | (c) Crohn's & Colitis Foundation of America, 2019 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties inflamatòries intestinals | - |
dc.subject.classification | Necrosi | - |
dc.subject.other | Inflammatory bowel diseases | - |
dc.subject.other | Necrosis | - |
dc.title | Effectiveness and Safety of the Sequential Use of a Second and Third Anti-TNF Agent in Patients With Inflammatory Bowel Disease: Results From the Eneida Registry | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 692115 | - |
dc.date.updated | 2021-02-05T13:49:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31504569 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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692115.pdf | 270.26 kB | Adobe PDF | View/Open |
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