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Title: Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
Author: Duart Castells, Leticia
Cantacorps, Lídia
López-Arnau, Raúl
Montagud-Romero, Sandra
Puster, Brigitte
Mera Nanín, Paula
Serra i Cucurull, Dolors
Camarasa García, Jordi
Pubill Sánchez, David
Valverde, Olga
Escubedo Rafa, Elena
Keywords: Alcohol
Ratolins (Animals de laboratori)
Mice (Laboratory animals)
Issue Date: 19-Jul-2020
Publisher: Oxford University Press
Abstract: Backgroud: Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders (FASD), including eating disorders and increased risk for substance abuse as very common issues. In this context, the present study aimed to assess the interaction between alcohol exposure during gestation and lactation periods (PLAE) and a high fat diet (HFD) during childhood and adolescence. Methods: Pregnant C57BL/6 mice underwent a procedure for alcohol binge drinking during gestation and lactation periods. Subsequently, PLAE female offspring were fed with a HFD for 8 weeks and thereafter, nutrition-related parameters as well as their response to cocaine were assessed. Results: In our model, feeding young females with a HFD increased their triglyceride blood levels but did not induce an overweight compared to those fed with a standard diet. Moreover, PLAE affected how females responded to the fatty diet as they consumed less amount of food than water-exposed offspring, consistent with a lower gain of body weight. HFD increased the psychostimulant effects of cocaine. Surprisingly, PLAE reduced the locomotor responses to cocaine without modifying cocaine-induced reward. Moreover, PLAE prevented the striatal overexpression of cannabinoid 1 receptors induced by a HFD and induced an alteration of myelin damage biomarker in the prefrontal cortex, an effect that was mitigated by a HFD-based feeding. Conclusion: Therefore, in female offspring, some effects triggered by one of these factors, PLAE or a HFD, were blunted by the other, suggesting a close interaction between the involved mechanisms.
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It is part of: International Journal of Neuropsychopharmacology, 2020, vol. 24, num. 1, p. 77-88
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ISSN: 1461-1457
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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