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Title: Spatiotemporal Analysis of Hydration Mechanism in Sodium Alginate Matrix Tablets
Author: Juszczyk, Ewelina
Kulinowski, Piotr
Baran, Ewelina
Birczynski, Artur
Majda, Dorota
García Montoya, Encarna
Pérez Lozano, Pilar
Suñé i Negre, Josep M. (Josep Maria)
Weglarz, Wladyslaw P.
Dorozynski, Przemyslaw
Keywords: Nanopartícules
Síntesi de fàrmacs
Drug synthesis
Issue Date: 21-Jan-2021
Publisher: MDPI
Abstract: Methods of spatiotemporal characterization of nonequilibrated polymer based matrices are still immature and imperfect. The purpose of the study was to develop the methodology for the spatiotemporal characterization of water transport and properties in alginate tablets under hydration. The regions of low water content were spatially and temporally sampled using Karl Fisher and Differential Scanning Callorimetry (spatial distribution of freezing/nonfreezing water) with spatial resolution of 1 mm. In the regions of high water content, where sampling was infeasible due to gel/sol consistency, magnetic resonance imaging (MRI) enabled characterization with an order of magnitude higher spatial resolution. The minimally hydrated layer (MHL), infiltration layer (IL) and fully hydrated layer (FHL) were identified in the unilaterally hydrated matrices. The MHL gained water from the first hour of incubation (5-10% w/w) and at 4 h total water content was 29-39% with nonfreezing pool of 28-29%. The water content in the IL was 45-47% and at 4 h it reached ~50% with the nonfreezing pool of 28% and T2 relaxation time < 10 ms. The FHL consisted of gel and sol layer with water content of 85-86% with a nonfreezing pool of 11% at 4 h and T2 in the range 20-200 ms. Hybrid destructive/nondestructive analysis of alginate matrices under hydration was proposed. It allowed assessing the temporal changes of water distribution, its mobility and interaction with matrices in identified layers.
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It is part of: Materials, 2021, vol. 14, p. 646-659
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ISSN: 1996-1944
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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