Please use this identifier to cite or link to this item:
Title: Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study
Author: Cocco, Pierluigi
Satta, Giannina
Meloni, Federico
Pilia, Ilaria
Ahmed, Fahad
Becker, Nikolaus
Casabonne, Delphine
Sanjosé Llongueras, Silvia de
Foretova, Lenka
Maynadié, Marc
Nieters, Alexandra
Staines, Anthony
Mannetje, Andrea ‘t
Zucca, Mariagrazia
Ennas, Maria Grazia
Campagna, Marcello
Matteis, Sara De
Benavente, Yolanda
Keywords: Limfomes
Malaltia de Hodgkin
Hodgkin's disease
Issue Date: 1-Jan-2021
Publisher: Nordic Association of Occupational Safety and Health (NOROSH)
Abstract: Objectives: This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts. Methods: We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case–control study, conducted in six European countries in 1998–2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education. Results: We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01–4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00–4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95–4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively). Conclusions: Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma.
Note: Reproducció del document publicat a:
It is part of: Scandinavian Journal of Work Environment & Health, 2021, vol. 47, num.1, p. 42-51
Related resource:
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
CoccoP.pdf395.55 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons