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Title: Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up)
Author: Dierssen Sotos, Trinidad
Gómez Acebo, Inés
Gutiérrez Ruiz, Nuria
Aragonès Sanz, Núria
Amiano, Pilar
Molina de la Torre, Antonio José
Guevara, Marcela
Alonso Molero, Jéssica
Obón Santacana, Mireia
Fernández Tardón, Guillermo
Molina Barceló, Ana
Alguacil, Juan
Marcos Gragera, Rafael
Rodríguez Cundín, Paz
Castaño-Vinyals, Gemma
Canseco Fernandez, Rosario
Castilla, Jesús
Molinuevo, Amaia
Pérez Gómez, Beatriz
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
Keywords: Càncer de mama
Pronòstic mèdic
Breast cancer
Issue Date: 1-Jan-2021
Publisher: MDPI
Abstract: The aim of this study was to characterize the relationship between the intake of the major nutrients and prognosis in breast cancer. A cohort based on 1350 women with invasive (stage I-IV) breast cancer (BC) was followed up. Information about their dietary habits before diagnosis was collected using a semi-quantitative Food Frequency Questionnaire. Participants without FFQ or with implausible energy intake were excluded. The total amount consumed of each nutrient (Kcal/day) was divided into tertiles, considering as “high intakes” those above third tertile. The main effect studied was overall survival. Cox regression was used to assess the association between death and nutrient intake. During a median follow-up of 6.5 years, 171 deaths were observed. None of the nutrients analysed was associated with mortality in the whole sample. However, in normal-weight women (BMI 18.5–25 kg/m2) a high intake of carbohydrates (≥809 Kcal/day), specifically monosaccharides (≥468 Kcal/day), worsened prognostic compared to lowest (≤352 Kcal/day). Hazard Ratios (HRs) for increasing tertiles of intake were HR:2.22 95% CI (1.04 to 4.72) and HR:2.59 95% CI (1.04 to 6.48), respectively (p trend = 0.04)). Conversely, high intakes of polyunsaturated fats (≥135 Kcal/day) improved global survival (HR: 0.39 95% CI (0.15 to 1.02) p-trend = 0.05) compared to the lowest (≤92.8 kcal/day). In addition, a protective effect was found substituting 100 kcal of carbohydrates with 100 kcal of fats in normal-weight women (HR: 0.76 95% CI (0.59 to 0.98)). Likewise, in premenopausal women a high intake of fats (≥811 Kcal/day) showed a protective effect (HR:0.20 95% CI (0.04 to 0.98) p trend = 0.06). Finally, in Estrogen Receptors (ER) negative tumors, we found a protective effect of high intake of animal proteins (≥238 Kcal/day, HR: 0.24 95% CI (0.06 to 0.98). According to our results, menopausal status, BMI and ER status could play a role in the relationship between diet and BC survival and must be taken into account when studying the influence of different nutrients.
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It is part of: International Journal of Environmental Research and Public Health, 2021, vol. 18, num. 1
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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