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Title: | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder |
Author: | Hernández Rubio, Anna Sanvisens, Arantza Bolao, Ferran Pérez Mañá, Clara García Marchena, Nuria Fernández Prendes, Carla Muñoz, Alvaro Muga, Roberto |
Keywords: | Hiperuricèmia Consum d'alcohol Hyperuricemia Drinking of alcoholic beverages |
Issue Date: | 18-Nov-2020 |
Publisher: | Nature Research |
Abstract: | Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120-240 g/day]. Body Mass Index was 24.7 kg/m(2) [IQR, 21.9-28.4 kg/m(2)], eGFR was 105 mL/min/1.73 m(2) [IQR, 95.7-113.0 mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4>3.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT <= 50, those with GGT between 51 and 300 U/L and those with GGT>300 U/L were 4.31 (95% CI 1.62-11.46) and 10.3 (95% CI 3.50-29.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-77013-1 |
It is part of: | Scientific Reports, 2020, vol. 10 |
URI: | http://hdl.handle.net/2445/173784 |
Related resource: | https://doi.org/10.1038/s41598-020-77013-1 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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