Please use this identifier to cite or link to this item:
Title: Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure
Author: Pironi, Loris
Steiger, Ezra
Joly, Francisca
Wanten, Geert
Chambrier, Cecile
Aimasso, Umberto
Sasdelli, Anna Simona
Szczepanek, Kinga
Jukes, Amelia
Theilla, Miriam
Kunecki, Marek
Daniels, Joanne
Serlie, Mireille
Cooper, Sheldon C.
Poullenot, Florian
Rasmussen, Henrik H.
Compher, Charlene
Crivelli, Adriana
Hughes, Sarah-Jane
Santarpia, Lidia
Guglielmi, Francesco W.
Kozjek, Nada Rotovnik
Ellegard, Lars
Schneider, Stéphane M.
Matras, Przemysław
Forbes, Alastair
Wyer, Nicola
Zmarzly, Anna
Taus, Marina
O'Callaghan, Margie
Osland, Emma
Thibault, Ronan
Cuerda Compes, Cristina
Jones, Lynn
Chapman, Brooke
Sahin, Peter
Virgili, Núria
Won Lee, Andre Dong
Orlandoni, Paolo
Matysiak, Konrad
Caro, Simona Di
Doitchinova Simeonova, Maryana
Masconale, Luisa
Spaggiari, Corrado
Garde, Carmen
Serralde Zúñiga, Aurora E.
Olveira, Gabriel
Krznaric, Zeljko
Jáuregui, Estrella Petrina
Zugasti Murillo, Ana
Suárez Llanos, José P.
Nardi, Elena
Van Gossum, Andrè
Lal, Simon
Keywords: Obstrucció intestinal
Alimentació parenteral
Intestinal obstruction
Parenteral feeding
Issue Date: 1-Oct-2020
Publisher: BMJ Publishing Group
Abstract: Background and aim: No marker to categorise the severity of chronic intestinal failure (CIF) has been developed. A 1-year international survey was carried out to investigate whether the European Society for Clinical Nutrition and Metabolism clinical classification of CIF, based on the type and volume of the intravenous supplementation (IVS), could be an indicator of CIF severity. Methods: At baseline, participating home parenteral nutrition (HPN) centres enrolled all adults with ongoing CIF due to non-malignant disease; demographic data, body mass index, CIF mechanism, underlying disease, HPN duration and IVS category were recorded for each patient. The type of IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorised as <1, 1-2, 2-3 and >3 L/day. The severity of CIF was determined by patient outcome (still on HPN, weaned from HPN, deceased) and the occurrence of major HPN/CIF-related complications: intestinal failure-associated liver disease (IFALD), catheter-related venous thrombosis and catheter-related bloodstream infection (CRBSI). Results: Fifty-one HPN centres included 2194 patients. The analysis showed that both IVS type and volume were independently associated with the odds of weaning from HPN (significantly higher for PN 1 L/day), patients' death (lower for FE, p=0.079), presence of IFALD cholestasis/liver failure and occurrence of CRBSI (significantly higher for PN 2-3 and PN >3 L/day). Conclusions: The type and volume of IVS required by patients with CIF could be indicators to categorise the severity of CIF in both clinical practice and research protocols.
Note: Versió postprint del document publicat a:
It is part of: Gut, 2020, vol. 69, num. 10, p. 1787-1795
Related resource:
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
PironiL.pdf1.04 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.