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Title: Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study
Author: Alonso Molero, Jéssica
Dierssen Sotos, Trinidad
Gómez Acebo, Inés
Fernández de Larrea Baz, Nerea
Guevara, Marcela
Amiano, Pilar
Castaño-Vinyals, Gemma
Fernández Villa, Tania
Moreno Aguado, Víctor
Bayo Calero, Juan
Molina Barceloa, Ana
Fernández Ortíz, María
Suarez Calleja, Claudia
Marcos Gragera, Rafael
Castells, Xavier
Gil Majuelo, Leire
Ardanaz, Eva
Pérez Gómez, Beatriz
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
Keywords: Càncer de mama
Qualitat de vida
Breast cancer
Quality of life
Issue Date: 1-Nov-2020
Publisher: MDPI
Abstract: Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017-2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run.
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It is part of: International Journal of Environmental Research and Public Health, 2020, vol. 17, num. 22
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Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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