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Title: Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
Author: Rubín García, María
Vitelli Storelli, Facundo
Molina de la Torre, Antonio José
Zamora-Ros, Raul
Aragonès Sanz, Núria
Adarnaz, Eva
Castaño-Vinyals, Gemma
Obón Santacana, Mireia
Gómez Acebo, Inés
Molina Barceló, Ana
Fernández Tardón, Guillermo
Jiménez Moleón, José Juan
Alguacil, Juan
Chirlaque, María Dolores
Toledo Atucha, Estefanía
Pérez Goóez, Beatriz
Pollán, Marina
Kogevinas, Manolis
Martín Sánchez, Vicente
Keywords: Càncer d'estómac
Stomach cancer
Issue Date: 1-Nov-2020
Publisher: MDPI
Abstract: Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.
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It is part of: Nutrients, 2020, vol. 12, num. 11
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Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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