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Title: | Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress |
Author: | Rezvani, Maryam Manca, Maria Letizia Caddeo, Carla Escribano Ferrer, Elvira Carbone, Claudia Peris, José Esteban Usach, Iris Diez-Sales, Octavio Fadda, Anna Maria Manconi, Maria |
Keywords: | Vitamina C Vitamina E Cicatrització Intestins Neuroimmunologia Vitamin C Vitamin E Wound healing Intestines Neuroimmunology |
Issue Date: | 2019 |
Publisher: | MDPI |
Abstract: | The present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit® L100), a water-soluble prebiotic fibre (Nutriose® FM06), a phospholipid mixture (Lipoid S75), and two natural antioxidants (ascorbic acid and tocopherol) were combined to fabricate eudragit-nutriosomes by a simple, solvent-free procedure. The vesicles were spherical and oligolamellar, with some multicompartment structures in Eudragit-nutriosomes, small in size (~100 nm), with highly negative zeta potential. The effect of Eudragit® and Nutriose® on the stability on storage and in simulated gastrointestinal fluids were confirmed by the Turbiscan® technology and in vitro studies, respectively. Eudragit-nutriosomes exhibited a protective effect against H2O2-induced oxidative stress, and a proliferative effect in Caco-2 cells, as they provided the closure of the scratched area after 96 h of incubation. Keywords: Eudragit, Nutriose, phospholipid vesicles, antioxidant, intestinal wound healing |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics11010013 |
It is part of: | Pharmaceutics, 2019, vol. 11, p. 13-22 |
URI: | http://hdl.handle.net/2445/173852 |
Related resource: | https://doi.org/10.3390/pharmaceutics11010013 |
ISSN: | 1999-4923 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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