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http://hdl.handle.net/2445/173920
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DC Field | Value | Language |
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dc.contributor.author | Moreno Manuel, Andrea | - |
dc.contributor.author | Jantus Lewintre, Eloisa | - |
dc.contributor.author | Simões, Inês | - |
dc.contributor.author | Aranda, Fernando | - |
dc.contributor.author | Calabuig Fariñas, Silvia | - |
dc.contributor.author | Carreras Margalef, Esther | - |
dc.contributor.author | Zúñiga, Sheila | - |
dc.contributor.author | Saenger, Yvonne | - |
dc.contributor.author | Rosell, Rafael | - |
dc.contributor.author | Camps, Carlos | - |
dc.contributor.author | Lozano Soto, Francisco | - |
dc.contributor.author | Sirera, Rafael | - |
dc.date.accessioned | 2021-02-12T11:57:23Z | - |
dc.date.available | 2021-02-12T11:57:23Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 2218-6751 | - |
dc.identifier.uri | http://hdl.handle.net/2445/173920 | - |
dc.description.abstract | Background: The study of immune surveillance in the tumour microenvironment is leading to the development of new biomarkers and therapies. The present research focuses on the expression of CD5 and CD6 - two lymphocyte surface markers involved in the fine tuning of TCR signaling - as potential prognostic biomarkers in resectable stages of non-small cell lung cancer (NSCLC). Methods: CD5 and CD6 gene expression was analysed by reverse transcription quantitative polymerase chain reaction (RTqPCR) in 186 paired fresh frozen tumour and normal tissue samples of resected NSCLC. Results: Patients with higher CD5 expression had significantly increased overall survival (OS, 49.63 vs. 99.90 months, p=0.013). CD5 expression levels were correlated to CD4 infiltration and expression levels, and survival analysis showed that patients with a higher CD5/CD4+ ratio had significantly improved prognosis. Multivariate analysis established CD5 expression as an independent prognostic biomarker for OS in early stages of NSCLC [HR=0.554; 95% CI, 0.360-0.853; p=0.007]. Further survival analysis of NSCLC cases (n=97) from The Cancer Genome Atlas (TCGA) database, confirmed the prognostic value of both CD5 and CD6 expression¸ although CD6 expression alone did not reach significant prognostic value in our NSCLC training cohort. Conclusions: Our data support further studies on CD5 and CD6 as novel prognostic markers in resectable NSCLC and other cancer types (i.e., melanoma), as well as a role for these receptors in immune surveillance. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | AME Publishing Company | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.21037/tlcr-19-445 | - |
dc.relation.ispartof | Translational Lung Cancer Research, 2020, vol. 9, num. 4, p. 1074-1083. | - |
dc.relation.uri | https://doi.org/10.21037/tlcr-19-445 | - |
dc.rights | cc-by-nc-nd (c) AME Publishing Company, 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Càncer de pulmó | - |
dc.subject.classification | Melanoma | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.other | Lung cancer | - |
dc.subject.other | Melanoma | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Tumor markers | - |
dc.title | CD5 and CD6 as immunoregulatory biomarkers in non-small cell lung cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 701649 | - |
dc.date.updated | 2021-02-12T11:57:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32953486 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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701649.pdf | 871.89 kB | Adobe PDF | View/Open |
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