Please use this identifier to cite or link to this item:
Title: Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes
Author: Dobaño, Carlota, 1969-
Bardají, Azucena
Arévalo Herrera, Myriam
Martínez Espinosa, Flor E.
Bôtto Menezes, Camila
Padilla, Norma
Menegon, Michela
Kochar, Swati
Kochar, Sanjay Kumar
Unger, Holger Werner
Ome-Kaius, Maria
Rosanas Urgell, Anna
Malheiros, Adriana
Castellanos, Maria Eugenia
Hans, Dhiraj
Desai, Meghna
Casellas, Aina
Chitnis, Chetan E.
Severini, Carlo
Mueller, Ivo
Rogerson, Stephen
Menéndez, Clara
Requena, Pilar
Keywords: Embaràs
Plasmodium vivax
Plasmodium vivax
Issue Date: 4-May-2020
Publisher: Public Library of Science (PLoS)
Abstract: Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma concentrations of a set of thirty-one biomarkers, comprising cytokines, chemokines and growth factors, in 987 plasma samples from a cohort of 572 pregnant women from five malaria-endemic tropical countries and related these concentrations to delivery outcomes (birth weight and hemoglobin levels) and malaria infection. Samples were collected at recruitment (first antenatal visit) and at delivery (periphery, cord and placenta). At recruitment, we found that P. vivax-infected pregnant women had higher plasma concentrations of proinflammatory (IL-6, IL-1\xCE\xB2, CCL4, CCL2, CXCL10) and TH1-related cytokines (mainly IL-12) than uninfected women. This biomarker signature was essentially lost at delivery and was not associated with birth weight nor hemoglobin levels. Antiinflammatory cytokines (IL-10) were positively associated with infection and poor delivery outcomes. CCL11 was the only biomarker to show a negative association with P. vivax infection and its concentration at recruitment was positively associated with hemoglobin levels at delivery. Birth weight was negatively associated with peripheral IL-4 levels at delivery. Our multi-biomarker multicenter study is the first comprehensive one to characterize the immunological signature of P. vivax infection in pregnancy thus far. In conclusion, data show that while TH1 and pro-inflammatory responses are dominant during P. vivax infection in pregnancy, antiinflammatory cytokines may compensate excessive inflammation avoiding poor delivery outcomes, and skewness toward a TH2 response may trigger worse delivery outcomes. CCL11, a chemokine largely neglected in the field of malaria, emerges as an important marker of exposure or mediator in this condition.
Note: Reproducció del document publicat a:
It is part of: PLoS Neglected Tropical Diseases, 2020, vol. 14, num. 5, p. e0008155
Related resource:
ISSN: 1935-2735
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (ISGlobal)

Files in This Item:
File Description SizeFormat 
Doba_o_C_PLoS_Negl_Trop_Dis_2020.pdf863.97 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons