Please use this identifier to cite or link to this item:
Title: Relationship of visceral adipose tissue with surrogate insulin resistance and liver markers in individuals with metabolic syndrome chronic complications
Author: Bullón Vela, Vanessa
Abete, Itziar
Tur, Josep Antoni
Konieczna, Jadwiga
Romaguera, Dora
Pinto, Xavier
Corbella, Emili
Martínez-González, Miguel Ángel, 1957-
Sayón Orea, Carmen
Toledo Atucha, Estefanía
Corella Piquer, Dolores
Macías González, Manuel
Tinahones, Francisco J.
Fitó Colomer, Montserrat
Estruch Riba, Ramon
Ros Rahola, Emilio
Salas Salvadó, Jordi
Daimiel, Lidia
Mascaró, Catalina M.
Zulet, M. Angeles
Martínez, J. Alfredo, 1957-
Keywords: Resistència a la insulina
Síndrome metabòlica
Malalties del fetge
Insulin resistance
Metabolic syndrome
Liver diseases
Issue Date: 1-Oct-2020
Publisher: Sage Publications Ltd
Abstract: Background: Visceral adipose tissue (VAT) has a hazardous influence on systemic inflammation, insulin resistance and an adverse metabolic profile, which increases the risk of developing non-alcoholic fatty liver disease (NAFLD) and chronic complications of diabetes. In our study we aimed to evaluate the association of VAT and the triglyceride glucose (TyG) as a proxy of insulin resistance surrogated with metabolic and liver risk factors among subjects diagnosed with metabolic syndrome (MetS). Methods: A cross-sectional study was performed including 326 participants with MetS (55-75 years) from the PREDIMED-Plus study. Liver-status markers, VAT and TyG were assessed. Participants were stratified by tertiles according to VAT (n = 254) and TyG (n = 326). A receiver operating characteristic curve was used to analyse the efficiency of TyG for VAT. Results: Subjects with greater visceral fat depots showed worse lipid profile, higher homeostatic model assessment for insulin resistance (HOMA-IR), TyG, alanine transaminase (ALT), fibroblast growth factor-21 (FGF-21), fatty liver index (FLI) and hepatic steatosis index (HSI) compared with participants in the first tertile. The multi-adjusted linear-regression analyses indicated that individuals in the third tertile of TyG (>9.1-10.7) had a positive association with HOMA-IR [beta = 3.07 (95% confidence interval (CI) 2.28-3.86; p trend < 0.001)], ALT [beta = 7.43 (95% CI 2.23-12.63; p trend = 0.005)], gamma glutamyl transferase (GGT) [beta = 14.12 (95% CI 3.64-24.61; p trend = 0.008)], FGF-21 [beta = 190.69 (95% CI 93.13-288.25; p trend < 0.001)], FLI [beta = 18.65 (95% CI 14.97-22.23; p trend < 0.001)] and HSI [beta = 3.46 (95% CI, 2.23-4.68; p trend < 0.001)] versus participants from the first tertile. Interestingly, the TyG showed the largest area under the receiver operating curve (AUC) for women (AUC = 0.713; 95% CI 0.62-0.79) compared with men (AUC = 0.570; 95% CI 0.48-0.66). Conclusions: A disrupted VAT enlargement and impairment of TyG are strongly associated with liver status and cardiometabolic risk factors linked with NAFLD in individuals diagnosed with MetS. Moreover, the TyG could be used as a suitable and reliable marker estimator of VAT.
Note: Reproducció del document publicat a:
It is part of: Therapeutic Advances In Endocrinology And Metabolism, 2020, Vol. 11 p. 1-15
Related resource:
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Files in This Item:
File Description SizeFormat 
Bullon-VelaV.pdf434.84 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons