Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/174061
Title: Chagas disease in the United Kingdom: A review of cases at the hospital for Tropical Diseases London 1995-2018. The current state of detection of Chagas disease in the UK
Author: González Sanz, Marta
Sario, Valentina De
García Mingo, Ana
Nolder, Debbie
Dawood, Naghum
Álvarez Martínez, Míriam
Daly, Rosemarie
Lowe, Patricia
Yacoub, Sophie
Moore, David A. J.
Chiodini, Peter L.
Keywords: Malaltia de Chagas
Gran Bretanya
Chagas' disease
Great Britain
Issue Date: Aug-2020
Publisher: Elsevier Ltd.
Abstract: Background: Chagas disease (CD), is a parasitic disease endemic in Latin America. Presentation in non-endemic areas is either in the asymptomatic indeterminate phase or the chronic phase with cardiac and/or gastrointestinal complications. Methods: The Hospital for Tropical Diseases (HTD) based in central London, provides tertiary care for the management of CD. We reviewed all cases managed at this centre between 1995 and 2018. Results: Sixty patients with serologically proven CD were identified. Most were female (70%), with a median age at diagnosis of 41 years. Three quarters of the patients were originally from Bolivia. 62% of all patients were referred to the HTD by their GP. Nearly half of the patients were asymptomatic (47%). Twelve patients had signs of cardiac involvement secondary to CD. Evidence of gastrointestinal damage was established in three patients. Treatment was provided at HTD for 31 patients (47%). Most patients (29) received benznidazole, five of them did not tolerate the course and were switched to nifurtimox. Of the seven patients receiving this second line drug, five completed treatment, whilst two interrupted it due to side effects. Conclusions: Despite the UK health system having all the resources required to diagnose, treat and follow up cases, there is lack of awareness of CD, such that the vast majority of cases remain undiagnosed and therefore do not receive treatment. We propose key interventions to improve the detection and management of this condition in the UK, especially in pregnant women and neonates.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1016/j.tmaid.2020.101760
It is part of: Travel Medicine and Infectious Disease, 2020, vol. 36
URI: http://hdl.handle.net/2445/174061
Related resource: http://dx.doi.org/10.1016/j.tmaid.2020.101760
Appears in Collections:Articles publicats en revistes (ISGlobal)

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