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http://hdl.handle.net/2445/174070
Title: | Exploring risk and resilient profiles for functional impairment and baseline predictors in a 2-year follow-up first-episode psychosis cohort using latent class growth analysis |
Author: | Salagre, Estela Grande i Fullana, Iria Solé, Brisa Mezquida Mateos, Gisela Cuesta, Manuel J. Díaz Caneja, Covadonga M. Amoretti Guadall, Silvia Lobo, Antonio González-Pinto, Ana Moreno, Carmen (Moreno Koch) Pina Camacho, Laura Corripio, Iluminada Baeza, Inmaculada, 1970- Bergé, Daniel Verdolini, Norma Carvalho, André F. Vieta i Pascual, Eduard, 1963- Bernardo Arroyo, Miquel PEPs Group |
Keywords: | Psicosi Trastorns de la cognició Psychoses Cognition disorders |
Issue Date: | 28-Dec-2021 |
Publisher: | MDPI |
Abstract: | Being able to predict functional outcomes after First-Episode Psychosis (FEP) is a major goal in psychiatry. Thus, we aimed to identify trajectories of psychosocial functioning in a FEP cohort followed-up for 2 years in order to find premorbid/baseline predictors for each trajectory. Additionally, we explored diagnosis distribution within the different trajectories. A total of 261 adults with FEP were included. Latent class growth analysis identified four distinct trajectories: Mild impairment-Improving trajectory (Mi-I) (38.31% of the sample), Moderate impairment-Stable trajectory (Mo-S) (18.39%), Severe impairment-Improving trajectory (Se-I) (12.26%), and Severe impairment-Stable trajectory (Se-S) (31.03%). Participants in the Mi-I trajectory were more likely to have higher parental socioeconomic status, less severe baseline depressive and negative symptoms, and better premorbid adjustment than individuals in the Se-S trajectory. Participants in the Se-I trajectory were more likely to have better baseline verbal learning and memory and better premorbid adjustment than those in the Se-S trajectory. Lower baseline positive symptoms predicted a Mo-S trajectory vs. Se-S trajectory. Diagnoses of Bipolar disorder and Other psychoses were more prevalent among individuals falling into Mi-I trajectory. Our findings suggest four distinct trajectories of psychosocial functioning after FEP.We also identified social, clinical, and cognitive factors associated with more resilient trajectories, thus providing insights for early interventions targeting psychosocial functioning. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm10010073 |
It is part of: | Journal of Clinical Medicine, 2021, vol. 10(1), num. 73 |
URI: | http://hdl.handle.net/2445/174070 |
Related resource: | https://doi.org/10.3390/jcm10010073 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Publicacions de projectes de recerca finançats per la UE |
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