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http://hdl.handle.net/2445/174095
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DC Field | Value | Language |
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dc.contributor.author | Florez, Helena | - |
dc.contributor.author | Hernández Rodríguez, José | - |
dc.contributor.author | Carrasco Jordan, Josep Lluís | - |
dc.contributor.author | Prieto González, Sergio | - |
dc.contributor.author | Muxí Pradas, África | - |
dc.contributor.author | Filella Pla, Xavier | - |
dc.contributor.author | Ruiz-Gaspa, Silvia | - |
dc.contributor.author | Gomez Puerta, José A. | - |
dc.contributor.author | Cid Xutglà, M. Cinta | - |
dc.contributor.author | Espinosa Garriga, Gerard | - |
dc.contributor.author | Monegal Brancós, Ana | - |
dc.contributor.author | Guañabens Gay, Núria | - |
dc.contributor.author | Peris Bernal, Pilar | - |
dc.date.accessioned | 2021-02-19T10:38:37Z | - |
dc.date.available | 2021-02-19T10:38:37Z | - |
dc.date.issued | 2020-09-10 | - |
dc.identifier.issn | 2056-5933 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174095 | - |
dc.description.abstract | Objective: The aim of this study was to identify the risk factors associated with fragility fracture (FF) development in glucocorticoid (GC)-treated patients. Methods: 127 patients (aged 62±18 years, 63% women) on GC-treatment (mean dose 14.5±14.1 mg/day and duration 47.7±69 months) were included. The clinical data collected included bone metabolism study (including gonadal axis), GC-treatment, disease activity, dual-energy X-ray absorptiometry analysis (evaluating densitometric osteoporosis (OP) and trabecular bone score (TBS) degraded microarchitecture values (DMA)), X-ray (assessing vertebral fractures (VF)), FRAX risk (GC-adjusted) and previous FF. Results: 17% of the patients had VF, 28% FF (VF and/or non-VF), 29% OP and 52% DMA. Patients with VF received more GC boluses (57.1% vs 29.5%, p=0.03), were older (68±13 vs 60±19 years, p=0.02), postmenopausal (100% vs 67%, p=0.02), had low testosterone levels (57% vs 11%, p=0.02), lower TBS values (1.119±0.03 vs 1.237±0.013, p<0.001) and higher FRAX risk (17.2±16 vs 9.3±7.6, p=0.003). Patients with FF showed higher accumulated GC doses (16.6±18.4 vs 11.1±12.9 g, p=0.046). On multivariate analysis, hypogonadism (OR 12.38; 95% CI 1.85 to >100, p=0.01) and having received GC boluses (OR 3.45; 95% CI 1.04 to 12.15, p=0.01) were the main factors related to VF. Hypogonadism (OR 7.03; 95% CI 1.47 to 38.37, p=0.01) and FRAX >20 (OR 7.08; 95% CI 1.28 to 53.71, p=0.02) were factors related to FF. Conclusion: Hypogonadism is the principal risk factor for developing fractures in GC-treated men and women, whereas receiving GC boluses is a major factor for VF. These results indicate the importance of evaluating the gonadal axis in these patients. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/rmdopen-2020-001355 | - |
dc.relation.ispartof | RMD Open, 2020, vol. 6, num. 2, p. e001355 | - |
dc.relation.uri | https://doi.org/10.1136/rmdopen-2020-001355 | - |
dc.rights | cc-by-nc (c) Florez et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Osteoporosi | - |
dc.subject.classification | Fractures | - |
dc.subject.classification | Densitat mineral òssia | - |
dc.subject.classification | Glucocorticoides | - |
dc.subject.other | Osteoporosis | - |
dc.subject.other | Fractures | - |
dc.subject.other | Bone density | - |
dc.subject.other | Glucocorticoids | - |
dc.title | Vertebral fracture risk in glucocorticoid-induced osteoporosis: the role of hypogonadism and corticosteroid boluses | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 707200 | - |
dc.date.updated | 2021-02-19T10:38:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32917834 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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707200.pdf | 441.54 kB | Adobe PDF | View/Open |
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