Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/174119
Title: | Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences |
Author: | Casanova, José David González Carrillo, Josefá Martín Jiménez, Jesús Cuenca Muñoz, Javier Muñoz Esparza, Carmen Siguero Álvarez, Marcos Escribá, Rubén Burillo Milla, Esther Pompa, José Luis de la Raya Chamorro, Ángel Gimeno, Juan Ramón Sabater Molina, María Bernabé García, Gregorio |
Keywords: | Malalties del cor Miocardiopaties Heart diseases Myocardiopathies |
Issue Date: | 1-Oct-2020 |
Publisher: | Mdpi |
Abstract: | Aims: Hypertrophic cardiomyopathy (HCM) is often accompanied by increased trabeculated myocardium (TM)-which clinical relevance is unknown. We aim to measure the left ventricular (LV) mass and proportion of trabeculation in an HCM population and to analyze its clinical implication. Methods and Results: We evaluated 211 patients with HCM (mean age 47.8 +/- 16.3 years, 73.0% males) with cardiac magnetic resonance (CMR) studies. LV trabecular and compacted mass were measured using dedicated software for automatic delineation of borders. Mean compacted myocardium (CM) was 160.0 +/- 62.0 g and trabecular myocardium (TM) 55.5 +/- 18.7 g. The percentage of trabeculated myocardium (TM%) was 26.7% +/- 6.4%. Females had significantly increased TM% compared to males (29.7 +/- 7.2 vs. 25.6 +/- 5.8, p < 0.0001). Patients with LVEF < 50% had significantly higher values of TM% (30.2% +/- 6.0% vs. 26.6% +/- 6.4%, p = 0.02). Multivariable analysis showed that female gender and neutral pattern of hypertrophy were directly associated with TM%, while dynamic obstruction, maximal wall thickness and LVEF% were inversely associated with TM%. There was no association between TM% with arterial hypertension, physical activity, or symptoms. Atrial fibrillation and severity of hypertrophy were the only variables associated with cardiovascular death. Multivariable analysis failed to demonstrate any correlation between TM% and arrhythmias. Conclusions: Approximately 25% of myocardium appears non-compacted and can automatically be measured in HCM series. Proportion of non-compacted myocardium is increased in female, non-obstructives, and in those with lower contractility. The amount of trabeculation might help to identify HCM patients prone to systolic heart failure. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm9103171 |
It is part of: | Journal of Clinical Medicine, 2020, Vol. 9 (10), num. 3171 |
URI: | https://hdl.handle.net/2445/174119 |
Related resource: | https://doi.org/10.3390/jcm9103171 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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CasanovaJD.pdf | 2.35 MB | Adobe PDF | View/Open |
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