Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/174131
Title: | A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides |
Author: | Martín Gómez, Helena Oliver-Cervelló, Lluís Sánchez Campillo, Iván Marchán Sancho, Vicente Ginebra, Maria Pau Mas Moruno, Carlos |
Keywords: | Materials biomèdics Pèptids Biomedical materials Peptides |
Issue Date: | 4-Jan-2021 |
Publisher: | Royal Society of Chemistry |
Abstract: | A novel and versatile toolkit approach for the functionalization of biomaterials of different nature is described. This methodology is based on the solid-phase conjugation of specific anchoring units onto a resin-bound azido-functionalized peptide by using click chemistry. A synergistic multifunctional peptidic scaffold with cell adhesive properties was used as a model compound to showcase the versatility of this new approach. Titanium, gold and polylactic acid surfaces were biofunctionalized by this method, as validated by physicochemical surface characterization with XPS. In vitro assays using mesenchymal stem cells showed enhanced cell adhesion on the functionalized samples, proving the capacity of this strategy to efficiently bioactivate different types of biomaterials. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1039/d0cc07463b |
It is part of: | Chemical Communications, 2021, vol. 57, num. 8, p. 982-985 |
URI: | http://hdl.handle.net/2445/174131 |
Related resource: | https://doi.org/10.1039/d0cc07463b |
ISSN: | 1359-7345 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
707114.pdf | 403.32 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.