Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/174195
Title: | Intratumoral heterogeneity and clonal evolution in liver cancer |
Author: | Losic, Bojan Craig, Amanda J. Villacorta-Martin, Carlos Martins-Filho, Sebastiao N. Akers, Nicholas Chen, Xintong Ahsen, Mehmet Eren von Felden, Johann Labgaa, Ismail Avola, Delia D' Allette, Kimaada Lira, Sergio A. Furtado, Glaucia C. Garcia-Lezana, Teresa Restrepo, Paula Stueck, Ashley Ward, Stephen C. Fiel, Maria I. Hiotis, Spiros P. Gunasekaran, Ganesh Sia, Daniela Schadt, Eric E. Sebra, Robert Schwartz, Myron Llovet i Bayer, Josep Maria Thung, Swan N. Stolovitzky, Gustavo Villanueva, Augusto |
Keywords: | Càncer de fetge Genètica molecular humana Liver cancer Human molecular genetics |
Issue Date: | 15-Jan-2020 |
Publisher: | Nature Publishing Group |
Abstract: | Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and immune cells. We investigate how these interactions reflect intra-tumor heterogeneity (ITH) by correlating regional neo-epitope and viral antigen burden with the regional adaptive immune response. Regional expression of passenger mutations dominantly recruits adaptive responses as opposed to hepatitis B virus and cancer-testis antigens. We detect different clonal expansion of the adaptive immune system in distant regions of the same tumor. An ITH-based gene signature improves single-biopsy patient survival predictions and an expression survey of 38,553 single cells across 7 regions of 2 patients further reveals heterogeneity in liver cancer. These data quantify transcriptomic ITH and how the different components of the HCC ecosystem interact during cancer evolution. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-019-14050-z |
It is part of: | Nature Communications, 2020, vol. 11, num. 291 |
URI: | http://hdl.handle.net/2445/174195 |
Related resource: | https://doi.org/10.1038/s41467-019-14050-z |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
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