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Title: Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort
Author: Peters, Susan
Gallo, Valentina
Vineis, Paolo
Middleton, Lefkos T.
Forsgren, Lars
Sacerdote, Carlotta
Sieri, Sabina
Kyrozis, Andreas
Chirlaque, María Dolores
Zamora-Ros, Raul
Hansson, Oskar
Petersson, Jesper
Katzke, Verena
Kühn, Tilman
Mokoroa, Olatz
Masala, Giovanna
Ardanaz, Eva
Panico, Salvatore
Bergmann, Manuela M.
Key, Timothy J.
Weiderpass, Elisabete
Ferrari, Pietro
Vermeulen, Roel
Keywords: Malaltia de Parkinson
Consum d'alcohol
Parkinson's disease
Drinking of alcoholic beverages
Issue Date: 1-May-2020
Publisher: Wiley
Abstract: Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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It is part of: Movement Disorders, 2020, vol. 35, num. 7, p. 1258-1263
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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