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Title: | Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort |
Author: | Peters, Susan Gallo, Valentina Vineis, Paolo Middleton, Lefkos T. Forsgren, Lars Sacerdote, Carlotta Sieri, Sabina Kyrozis, Andreas Chirlaque, María Dolores Zamora-Ros, Raul Hansson, Oskar Petersson, Jesper Katzke, Verena Kühn, Tilman Mokoroa, Olatz Masala, Giovanna Ardanaz, Eva Panico, Salvatore Bergmann, Manuela M. Key, Timothy J. Weiderpass, Elisabete Ferrari, Pietro Vermeulen, Roel |
Keywords: | Malaltia de Parkinson Consum d'alcohol Parkinson's disease Drinking of alcoholic beverages |
Issue Date: | 1-May-2020 |
Publisher: | Wiley |
Abstract: | Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/mds.28039 |
It is part of: | Movement Disorders, 2020, vol. 35, num. 7, p. 1258-1263 |
URI: | http://hdl.handle.net/2445/174212 |
Related resource: | https://doi.org/10.1002/mds.28039 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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