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|Title:||Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort|
Middleton, Lefkos T.
Chirlaque, María Dolores
Bergmann, Manuela M.
Key, Timothy J.
|Keywords:||Malaltia de Parkinson|
Drinking of alcoholic beverages
|Abstract:||Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.|
|Note:||Reproducció del document publicat a: https://doi.org/10.1002/mds.28039|
|It is part of:||Movement Disorders, 2020, vol. 35, num. 7, p. 1258-1263|
|Appears in Collections:||Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))|
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