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Title: Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
Author: Cordero, Elisa
Bulnes Ramos, Angel
Aguilar Guisado, Manuela
González Escribano, Francisca
Olivas, Israel
Torre Cisneros, Julián
Gavaldà, Joan
Aydillo, Teresa
Moreno, Asunción
Montejo, Miguel
Fariñas, María Carmen
Carratalà, Jordi
Muñoz, Patricia
Blanes, Marino
Fortún, Jesús
Suarez Benjumea, Alejandro
López Medrano, Francisco
Roca, Cristina
Lara, Rosario
Pérez Romero, Pilar
Keywords: Citomegalovirus
Vacunes antivíriques
Influenza viruses
Viral vaccines
Issue Date: 6-Oct-2020
Publisher: Frontiers Media
Abstract: Introduction: Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Methods: Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRA(TM)Screening Test) by flow cytometry. Anti-HLA antibody specificity was determined using the single-antigen bead flow cytometry (SAFC) assay and assignation of donor specific antibodies (DSA) was performed by virtual-crossmatch. Results: We studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%;P= 0.003). Patients with pre-existing antibodies before vaccination (15.7% for anti-HLA class I and 15.9% for class II) did not increase reactivity after immunization. A group of 75 (14.4%) patients developedde novoanti-HLA antibodies, however, only 5 (1.02%) of them were DSA, and none experienced allograft rejection. Only two (0.4%) patients were diagnosed with graft rejection with favorable outcomes and neither of them developed DSA. Conclusion: Our results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR.
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It is part of: Frontiers in Immunology, 2020, vol. 11
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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