Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/174233
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brena, David | - |
dc.contributor.author | Bertran, Joan | - |
dc.contributor.author | Porta de la Riva, Montserrat | - |
dc.contributor.author | Guillen, Yolanda | - |
dc.contributor.author | Cornes, Eric | - |
dc.contributor.author | Kukhtar, Dmytro | - |
dc.contributor.author | Campos Vicens, Lluís | - |
dc.contributor.author | Fernández, Lierni | - |
dc.contributor.author | Pecharroman, Irene | - |
dc.contributor.author | García López, Albert | - |
dc.contributor.author | Islam, Abul B. M. M. K. | - |
dc.contributor.author | Marruecos, Laura | - |
dc.contributor.author | Bigas Salvans, Anna | - |
dc.contributor.author | Cerón Madrigal, Julián | - |
dc.contributor.author | Espinosa, Lluís | - |
dc.date.accessioned | 2021-02-23T18:43:58Z | - |
dc.date.available | 2021-02-23T18:43:58Z | - |
dc.date.issued | 2020-09-30 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174233 | - |
dc.description.abstract | Mammalian I kappa B proteins (I kappa Bs) exert their main function as negative regulators of NF-kappa B, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for I kappa Bs has been shown to affect stemness and cell differentiation. However, the involvement of NF-kappa B in this function has not been excluded. NFKI-1 and IKB-1 are I kappa B homologs in Caenorhabditis elegans, which lacks NF-kappa B nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans I kappa Bs in chromatin regulation. Further supporting this possibility (1) we detected NFKI-1 in the nucleus of cells; (2) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (3) and associate with chromatin in vivo, and (4) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral I kappa B inhibitors modulate Polycomb activity at specific gene subsets with an impact on development. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Research | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-73146-5 | - |
dc.relation.ispartof | Scientific Reports, 2020, vol. 10 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-020-73146-5 | - |
dc.rights | cc by (c) Brena et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Anàlisi de proteïnes | - |
dc.subject.classification | Nematodes | - |
dc.subject.other | Analysis of proteins | - |
dc.subject.other | Nematodes | - |
dc.title | Ancestral function ofInhibitors-of-kappaB regulates Caenorhabditis elegans development | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-02-08T10:33:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32999373 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
BrenaD.pdf | 5.17 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License